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41º Congreso de la Sociedad Española de Medicina Interna (SEMI) - VIRTUAL
Virtual, 23-27 noviembre 2020
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11. RIESGO VASCULAR
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RV-019 - METABOLICALLY HEALTHY OBESITY: PRESENCE OF ARTERIAL STIFFNESS IN THE PREPUBESCENT POPULATION

M.I. Ruiz Moreno1, A. Vilches Pérez2, C. Gallardo Escribano3, A. Gallardo Escribano1, A. Ruiz Moreno1, R. Bernal López1 and R. Gómez Huelgas1

1Departamento de Medicina Interna. Hospital Civil. Málaga. 2Departamento de Endocrinología y Nutrición. Hospital Clínico Universitario Virgen de la Victoria. Málaga. 3Departamento de Análisis Clínicos. Hospital Regional Universitario de Málaga. Málaga.

Objectives: Our aim was to assess the clinical, analytical, and dietary variables associated with arterial stiffness, measured by pulse wave velocity in a prepubescent population with metabolically healthy obesity.

Methods: A cross-sectional study in prepubescent subjects with obesity who had 1 or none metabolic syndrome criteria (abdominal perimeter and blood pressure ≥ 90th percentile, triglycerides > 150 mg/dL, HDL-cholesterol 100 mg/dL) were conducted. Adherence to Mediterranean Diet, blood pressure, BMI, waist/height ratio (WHtR), glycemic status, lipid profile, and carotid-femoral PWV were analyzed.

Results: 75 MHO children (boys: 43; girls: 32; p = 0.20) (age = 10.05 ± 1.29 years; BMI = 25.29 ± 3.5 kg/m2) were included. We found a positive correlation between carotid-femoral PWV and weight (r = 0.51; p < 0.0001), BMI (r = 0.44; p < 0.0001), WHtR (r = 0.26; p = 0.02), fasting insulin levels (r = 0.28; p = 0.02), and insulin resistance (HOMA-IR index) (r = 0.25; p = 0.04). Multiple linear regression analysis identified BMI and HOMA-IR as independent parameters associated with PWV.

Conclusions: In MHO prepubescent children, BMI and insulin-resistance status are related to arterial stiffness. PWV could potentially be a useful non-invasive technique to identify cardiovascular risk in childhood.

Bibliography

  1. Gómez-Huelgas R, Ruiz-Nava J, Santamaria-Fernández S, Vargas Candela A, Alarcon-Martín AV, Tinahones FJ, Bernal-López MR. Impact of intensive lifestyle modification on levels of adipokines and inflammatory biomarkers in metabolically healthy obese women. Mediators of Inflammation. 2019:4165260.

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Revista Clínica Española

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