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            "nombre" => "M&#46;B&#46;"
            "apellidos" => "Coco-Mart&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0045"
              ]
            ]
          ]
          9 => array:4 [
            "nombre" => "J&#46;L&#46; P&#233;rez"
            "apellidos" => "Castrill&#243;n"
            "email" => array:1 [
              0 => "uvacastrv@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">j</span>"
                "identificador" => "aff0050"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
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          ]
          10 => array:2 [
            "colaborador" => "on behalf of the OSTEOMED Group"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#9674;</span>"
                "identificador" => "fn1"
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          ]
        ]
        "afiliaciones" => array:10 [
          0 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital Universitario Albacete&#44; Albacete&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital Universitario Insular&#44; Las Palmas de Gran Canaria&#44; Las Palmas&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Fundaci&#243;n Jim&#233;nez D&#237;az&#44; Madrid&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital de la Princesa&#44; Madrid&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital Cl&#237;nico San Carlos&#44; Madrid&#44; Spain"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital Universitario Virgen Macarena&#44; Sevilla&#44; Spain"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#44; Spain"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
          7 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital Universitario Marqu&#233;s de Valdecilla&#44; Santander&#44; Cantabria&#44; Spain"
            "etiqueta" => "h"
            "identificador" => "aff0040"
          ]
          8 => array:3 [
            "entidad" => "Grupo de Investigaci&#243;n en Neurociencias Cl&#237;nicas Aplicadas&#44; Universidad de Valladolid&#44; Valladolid&#44; Spain"
            "etiqueta" => "i"
            "identificador" => "aff0045"
          ]
          9 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital Universitario R&#237;o Hortega&#44; Valladolid&#44; Spain"
            "etiqueta" => "j"
            "identificador" => "aff0050"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Perfil de los pacientes que acuden al m&#233;dico internista para valoraci&#243;n de osteoporosis&#58; registro OSTEOMED"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Osteoporosis is a generalized skeletal disorder in which there is impaired bone resistance that predisposes the individual to a greater risk of fracture&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> especially of the hip&#44; spine&#44; and wrist&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Osteoporosis is a disease that is associated with aging and as such&#44; it represents a problem of great magnitude and growing importance&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In Spain&#44; it is estimated that approximately three million people have osteoporosis&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> the majority of which are women&#46; In fact&#44; nearly 30&#37; of postmenopausal women have osteoporosis&#44; although many &#40;around 40&#37;&#41; have not yet been diagnosed&#46; Therefore&#44; its prevalence is likely underestimated&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> A lack of knowledge of the clinical characteristics of patients with osteoporosis could contribute to this&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In developed countries&#44; it is expected that 50&#37; of women and 20&#37; of men over 50 years of age will have a fracture due to bone fragility at some point in their lives&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> This is a great challenge for healthcare systems&#44; including Spain&#39;s healthcare system&#44; both from an economic and clinical point of view&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;7</span></a> In fact&#44; due to its prevalence and societal and health implications&#44; the World Health Organization &#40;WHO&#41; has defined osteoporosis as one of the two main health problems in Western countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> It has indicated specific actions in both primary and secondary care in order to decrease the alarming figures&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Osteoporosis is a highly multifactorial process<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> from an etiopathogenic point of view&#46; The main risk factors are age&#44; lack of estrogen&#44; and certain diseases and their treatment&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Furthermore&#44; various specialties converge in the field of osteoporosis&#44; among which internal medicine plays a notable role&#46; The internist is one of the most qualified physicians for the diagnosis and treatment of osteoporosis due to their comprehensive view of the patient&#46; For these reasons&#44; and fundamentally in order to improve knowledge of osteoporosis and the characteristics of patients with this disease who consult in internal medicine departments in Spain&#44; the OSTEOMED &#40;Osteoporosis in Internal Medicine&#41; registry was created in 2011 within the Spanish Society of Internal Medicine&#39;s Osteoporosis Working Group &#40;GTO&#44; for its initials in Spanish&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The aim of this study is to learn the demographic and clinical characteristics of patients with osteoporosis cared for in internal medicine departments in order to be able to establish effective diagnostic and treatment measures&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study design</span><p id="par0035" class="elsevierStylePara elsevierViewall">This cross-sectional study conducted from 2012 to 2017 evaluated the main clinical characteristics of patients with osteoporosis who consulted in the internal medicine clinics of 23 Spanish hospitals&#46; The majority of these departments had specific clinics dedicated to diagnosis and follow-up on patients with osteoporosis&#46; The reasons for consultation&#44; lifestyle-related factors&#44; previous treatment&#44; and presence of comorbidities were analyzed&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients</span><p id="par0040" class="elsevierStylePara elsevierViewall">Of patients referred to an internal medicine clinic for the evaluation or diagnosis of osteoporosis&#44; this work included those diagnosed with osteoporosis according to the densitometric criteria established by the WHO<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> &#40;<span class="elsevierStyleItalic">T</span>-score &#60;&#8722;2&#46;5 in any location&#41; or the presence of typical fractures due to fragility &#40;vertebral&#44; humerus&#44; or hip&#41; regardless of bone mineral density &#40;BMD&#41;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> and follow-up according to habitual clinical practice&#46; This meant that no diagnostic tests or therapeutic interventions apart from those that are habitual were performed nor was the frequency of visits changed&#46; Patients were referred from primary care&#44; other hospital departments&#44; or other clinics within the internal medicine department&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with neoplasms&#44; a life expectancy less than 12 months&#44; severe associated illness&#44; or who were over 90 years of age were excluded given that study and follow-up in the proposed manner was not feasible&#46; All patients included received a patient information sheet about the study and signed an informed consent form prior to their data being included in the system&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Study variables</span><p id="par0050" class="elsevierStylePara elsevierViewall">The variables collected in the study are those included on the medical record with a specific focus on osteoporosis and fractures&#46; They were incorporated into a Microsoft Access database called OSTEOMED&#46; On the patient&#39;s first visit&#44; the internist performed a clinical evaluation that included&#44; among other things&#44; the reason for the initial consultation and gathering of the patient&#39;s descriptive and epidemiological data&#44; lifestyle characteristics&#44; fertility history &#40;for women&#41;&#44; prior treatment&#44; and comorbidities&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Calcium consumption was determined based on weekly intake of dairy products &#40;milk&#44; cheese&#44; yogurt&#41;&#46; Sun exposure was defined as very low if the individual went outside less than four days per week&#44; sufficient if they went outside more than four days&#44; and high if they also received sun exposure on uncovered areas of the body for more than 20<span class="elsevierStyleHsp" style=""></span>min&#46; Physical activity was classified as light if they did less than 3<span class="elsevierStyleHsp" style=""></span>h of activity per week&#44; moderate if they did more than 3<span class="elsevierStyleHsp" style=""></span>h per week&#44; and sedentary if they did not do any physical activity&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Secondary osteoporosis was defined as when the patient presented with a disease associated with osteoporosis and the principal investigator considered it to be responsible for the osteoporosis&#46; Falls were recorded on the patient&#39;s medical record which&#44; as indicated&#44; had a specific focus on osteoporosis&#59; this was an important piece of data in the anamnesis&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Likewise&#44; laboratory data &#40;complete blood count&#44; biochemistry&#44; calcium metabolism parameters&#44; vitamin D&#44; PTH&#44; and bone remodeling markers&#41;&#44; bone densitometry&#44; imaging tests &#40;plain X-rays&#41;&#44; and treatment prescribed for associated medical processes were included&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0070" class="elsevierStylePara elsevierViewall">The data are presented as means<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation for continuous variables and as number of subjects and percentage for categorical variables&#46; Once the normality of the distribution of variables was analyzed&#44; the Student&#39;s <span class="elsevierStyleItalic">T</span>-test for independent samples was used to evaluate if there were significant differences in the means of subjects&#8217; continuous variables according to sex&#46; To verify if there were significant differences in the distribution of subjects&#8217; categorical variables&#44; the chi-square test was used for all variables in which more than 80&#37; of resulting cells on the contingency table had a value equal to or greater than 5&#46; On the contrary&#44; Fisher&#39;s exact test was used&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The Stata 13&#46;0 statistical software package for Mac was used to perform the statistical analyses&#46; The level of significance was established as <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethical considerations</span><p id="par0080" class="elsevierStylePara elsevierViewall">This study was approved by the University Hospital of Albacete Clinical Research Ethics Committee &#40;Minutes 02&#47;11&#41; and followed the recommendations of the Declaration of Helsinki&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall">A total of 2024 patients who consulted in 23 Spanish hospitals between 2012 and 2017 were evaluated&#44; of which 1819 were women &#40;89&#46;87&#37;&#41; and 205 were men &#40;10&#46;13&#37;&#41;&#46; The main descriptive characteristics of the sample on the first visit to the internist are indicated in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Patients&#8217; mean age was 64&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;1 years &#40;women&#58; 64&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;5 years&#59; men&#58; 61&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;2 years&#41; and body mass index was 26&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;6<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> &#40;women&#58; 26&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;7<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#59; men&#58; 26&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;2<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46; A total of 2&#46;87&#37; of patients were younger than 50 years of age&#44; 8&#46;75&#37; were between 50 and 59 years of age&#44; 23&#46;12&#37; were between 60 and 69 years of age&#44; 33&#46;50&#37; were between 70 and 79 years of age&#44; and 31&#46;77&#37; were older than 80 years of age&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The highest percentage of fractures was observed in the group of patients between 70 and 79 years of age &#40;157 total&#58; 151 in women and 6 in men&#41;&#44; followed by the group older than 80 years of age &#40;118 total&#58; 105 in women and 13 in men&#41;&#44; the group between 60 and 69 years of age &#40;101 total&#58; 91 in women and 10 in men&#41;&#44; the group between 50 and 59 years of age &#40;26 total&#58; 20 in women and 6 in men&#41;&#44; and those younger than 50 years of age &#40;4 total&#58; 4 in women and none in men&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The women&#39;s mean age of menopause was 48&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;3 years&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">There were no differences between sexes in regard to history of recent falls &#40;9&#46;1&#37; in men vs&#46; 6&#46;7&#37; in women&#41;&#44; whereas there was a significant difference in daily calcium intake from dairy products &#40;553&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>332&#46;6<span class="elsevierStyleHsp" style=""></span>mg in women vs&#46; 450&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>303&#46;3<span class="elsevierStyleHsp" style=""></span>mg in men&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; and secondary causes of osteoporosis &#40;13&#37; in men vs&#46; 6&#46;5&#37; in women&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; A total of 17&#46;2&#37; of patients had a prior densitometry &#40;16&#46;2&#37; of women vs&#46; &#60;1&#37; of men&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;004&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The main reasons for consultation &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41; were confirmed vertebral fractures &#40;17&#46;2&#37; total&#58; 35&#46;6&#37; in men vs&#46; 15&#46;2&#37; in women&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; non-vertebral fractures &#40;9&#46;1&#37; total&#41;&#44; back pain or kyphosis &#40;9&#46;8&#37; total&#41;&#44; musculoskeletal pain &#40;11&#46;4&#37; total&#41;&#44; breast cancer treatment &#40;10&#46;3&#37; total&#41;&#44; and suspected secondary osteoporosis &#40;7&#46;2&#37; total&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">In addition&#44; there was an &#8220;other reasons&#8221; section which included the majority of patients &#40;27&#46;9&#37;&#41;&#46; &#8220;Other reasons&#8221; was used when the reason for the consultation was not clearly indicated or made reference to other situations&#44; such as treatment failure&#44; adverse effects related to medication&#44; renal lithiasis&#44; alcohol use disorder&#44; celiac disease&#44; frequent falls&#44; abnormal analytical tests related to calcium and phosphorus metabolism&#44; tumors that were not of the prostate or breast&#44; radiological abnormalities&#44; osteopenia or osteoporosis with borderline densitometries&#44; screenings&#44; or referrals from other specialties&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The physical activity patterns did not differ between the sexes&#44; but the majority of patients appeared not to comply with WHO recommendations &#40;150<span class="elsevierStyleHsp" style=""></span>min per week of moderate physical activity&#44; 75<span class="elsevierStyleHsp" style=""></span>min per week of vigorous physical activity&#44; or an equivalent sum of both<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#41;&#59; 36&#46;2&#37; of women and 31&#46;4&#37; of men were sedentary and only 2&#8211; 6&#37; walked or actively climbed stairs regularly&#46; In addition&#44; 29&#46;8&#37; of women and 19&#46;7&#37; of men did light physical activity&#46; A similar percentage did moderate physical activity &#40;20&#46;4&#37; and 27&#46;4&#37;&#44; respectively&#41;&#46; Likewise&#44; 23&#46;2&#37; of the sample had very low sun exposure&#44; with differences observed between men and women &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;038&#41;&#46; Of the men&#44; 17&#37; were active smokers and 26&#46;5&#37; were ex-smokers versus 10&#46;7&#37; and 12&#46;4&#37; of women&#44; respectively &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; A total of 12&#46;6&#37; of men consumed alcohol in excess &#40;three or more drinks per day&#41; versus 1&#46;2&#37; of women &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">Patients&#8217; prior treatments were separated into drugs or other types of therapy with unfavorable effects on bone metabolism or fracture risk on the one hand and treatments for osteoporosis on the other &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; The first group included breast cancer treatment&#44; treatment with aromatase inhibitors &#40;12&#37; of women&#41;&#44; chemotherapy &#40;7&#37;&#41;&#44; and radiotherapy &#40;8&#37;&#41;&#46; Nine percent of patients received corticosteroids &#40;4&#46;8&#37; previously and 4&#46;6&#37; at the time of consultation&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Patients&#8217; medical records showed that 47&#37; had received or were in treatment for osteoporosis &#40;calcium&#58; 35&#37;&#59; vitamin D&#58; 38&#37;&#59; bisphosphonates&#58; 22&#37;&#59; other&#58; 12&#37;&#41;&#44; with lower percentages observed in men&#46; A small number of patients &#40;5&#46;8&#37;&#41; reported problems with osteoporosis treatment&#44; with just two cases of this in men &#40;0&#46;1&#37;&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">In regard to comorbidities &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;&#44; hypertension &#40;32&#37;&#41; and dyslipidemia &#40;28&#37;&#41; were of note&#46; Other diseases that merit mention were hypothyroidism &#40;10&#37;&#41;&#44; diabetes mellitus &#40;8&#37;&#41;&#44; nephrolithiasis &#40;7&#37;&#41;&#44; primary hyperparathyroidism &#40;3&#46;7&#37;&#41;&#44; and breast cancer &#40;15&#37; of women&#41;&#44; as indicated above&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">The data from this study reflect the clinical and demographic characteristics of patients with osteoporosis attended to in internal medicine clinics&#44; with special attention paid to the associated diseases and lifestyles of these patients&#46; Knowing these characteristics facilitates establishing action plans that allow for improving the care of these patients so that it is more effective and efficient&#46; These data are in line with the existing scientific literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Along these lines&#44; it is notable that 14&#37; of men presented with secondary causes of osteoporosis&#44; that is a loss of BMD or an increase in fracture risk as a consequence of other causes &#40;medication or other diseases&#41; apart from the aging process&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In regard to the main descriptive data&#44; a mean age of 64 years was found&#44; which is lower than the most recent reference studies &#40;72&#8211;74 years&#41;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a> and therefore&#44; a low incidence of previous fractures and falls was also to be expected&#46; The age of menarche in women was around the mean found in the literature whereas the age of menopause &#40;48 years&#41; was lower than the normal mean &#40;51 years&#41;&#44; which was to be expected given that early menopause is a risk factor for osteoporosis&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Daily intake of calcium from dairy products was lower among men &#40;450<span class="elsevierStyleHsp" style=""></span>mg&#41; than among women &#40;554<span class="elsevierStyleHsp" style=""></span>mg&#41; and these were somewhat lower than in other studies &#40;684<span class="elsevierStyleHsp" style=""></span>mg in the INDICAD 2001 study&#44; 808<span class="elsevierStyleHsp" style=""></span>mg in the Albacete cohort&#41;&#46; However&#44; the interpretation of this difference is complex because of the difficulties of rigorously gathering data on lifestyle&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">The studied sample had low levels of physical activity and high levels of sedentarism&#44; with figures that were similar in both sexes&#46; Likewise&#44; half of the women had very low sun exposure&#59; this parameter was somewhat better in the men &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Like other chronic diseases&#44; osteoporosis may have an important multifactorial origin which could include lifestyle&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Physical activity and a proper amount of sun exposure are fundamental to both the treatment and prevention of BMD loss&#46; Through exercise&#44; osteocytes are activated&#44; releasing a series of soluble factors &#40;nitric oxide&#44; bone morphogenetic proteins&#44; prostaglandin E2&#44; Wnt signaling pathways&#44; sclerostin&#44; RANKL&#41; which increase bone mass and improve its biomechanical capacity&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> In addition&#44; it is known that the muscle can synthesize myokines&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> which can have anabolic and anti-inflammatory effects that could improve bone quality and increase BMD&#46; Likewise&#44; adequate sun exposure can increase vitamin D production&#44; which is essential for maintaining proper BMD&#44; given that it helps with calcium absorption in the intestine and also facilitates bone mineralization&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> The two main sources of vitamin D are sun exposure and dietary supplements&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Tobacco use was present mainly in men&#44; although the fact that 32&#37; were ex-smokers could be considered a positive finding&#46; Tobacco is a risk factor for a decrease in BMD in both men and women&#46; Excess alcohol consumption was found almost exclusively among men in our sample &#40;14&#37;&#41;&#46; Alcohol use disorder is a risk factor for fractures in males that is multifactorial in origin&#44; due to nutritional deficits in calcium&#44; vitamin D&#44; and protein&#59; hypogonadism&#59; and a propensity to falling&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">An important section of the medical record was drugs with unfavorable effects on bone metabolism&#46; Treatment with aromatase inhibitors constituted the main group&#59; it affected 12&#37; of women who consulted and this percentage is likely increasing&#46; Nine percent of patients had received corticosteroids &#40;4&#46;8&#37; previously and 4&#46;6&#37; at the time of consultation&#41;&#46; The harmful effects of corticosteroids on bone are well-known&#46; Therefore&#44; it is necessary to actively identify&#44; evaluate&#44; and diagnose these patients and in this regard&#44; internal medicine departments must play a key role&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Although the percentage of patients with corticosteroids compared to all patients was low in our study&#44; the majority did not receive protective treatment for preventing bone complications&#44; which mainly includes the increase in fracture risk&#44; especially in the first six months from the start of treatment&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Patients&#8217; medical records showed that approximately half of them had previously been treated for osteoporosis &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#44; with a high percentage of women and 34&#37; of men&#46; The main treatments in the cohort studied were supplementation with calcium and vitamin D and the use of bisphosphonates as drugs&#59; a low number of patients had adverse effects to these medications&#46; Calcium is an important mineral that is essential to various functions&#44; including the formation and maintenance of healthy bones&#46; It is essential that an adequate peak bone mass is achieved&#44; although there is no universal criterion regarding the necessary daily dose according to age&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Bone is constantly being remodeled and therefore&#44; calcium intake throughout life is essential&#46; However&#44; calcium and vitamin D supplementation is not sufficient for treating subjects with osteoporosis&#44; despite the fact that it is useful&#44; especially in older institutionalized women&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Twenty-five percent of women and 18&#37; of men had received bisphosphonates&#44; which are the most used drugs worldwide for the prevention and treatment of osteoporosis &#40;any of the four options&#58; alendronate&#44; risedronate&#44; ibandronate&#44; and zolendronate&#41;&#46; Their main mechanism of action is inhibition of bone resorption&#44; decreasing the effect of osteoclasts by blocking the action of the farnesyl pyrophosphate synthase enzyme<span class="elsevierStyleItalic">&#46;</span> This generates isoprenoid lipids that are used for post-translation modifications of small proteins that bind to guanosine triphosphate that are necessary for the viability and function of osteoclasts&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0195" class="elsevierStylePara elsevierViewall">Other drugs represented 12&#37; of treatments&#46; They included denosumab&#44; which was received by a small number of patients given that the majority of patients in the cohort were included in 2011&#8211;2014&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">The other key section for internists was comorbidities&#46; Around one third of patients &#40;men and women&#41; presented with hypertension and a similar number with dyslipidemia&#46; The majority of the remaining diseases were breast cancer &#40;indicated above&#41; and endocrine-metabolic problems with a very direct relationship to the bone&#58; hypothyroidism&#44; diabetes mellitus&#44; nephrolithiasis&#44; and primary hyperparathyroidism&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Although the mean age was not very high with respect to the population attended to in internal medicine departments&#44; comorbidities &#8211; hypertension and dyslipidemia especially &#8211; were frequent&#46; An increase in the volume and complexity of concomitant disease is to be expected in elderly people&#44; which makes their management difficult&#46; This highlights the importance of a comprehensive clinical evaluation of the patient&#44; which entails systematically studying their medical record with all fundamental data on osteoporosis and comorbidities&#46; The internist must play a key role in this task&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a></p><p id="par0210" class="elsevierStylePara elsevierViewall">Few studies in other medical specialties have evaluated the profile of their patients&#46; The RETTOS study&#44; sponsored by the Spanish Society of Rheumatology&#44; included 629 women who had a very similar profile to those in our study&#44; although it did not consider associated diseases or the reported treatments&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> Some smaller studies conducted in endocrinology clinics have focused on secondary forms of the disease&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">The main limitation of our study was predetermined by its retrospective nature&#44; which made the homogeneous collection of data difficult&#46; Its strengths include the sample size and analysis of associated comorbidities&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Upon analyzing patients attended to in internal medicine clinics&#44; the associated comorbidities are of note&#46; They entail greater complexity and make the therapeutic management of these patients difficult&#46; In men&#44; there seems to be a higher percentage of secondary causes of osteoporosis&#46; A large part of patients did not receive an indicated treatment and they presented with low levels of physical activity and sun exposure&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">These results define the profile of patients with osteoporosis who consult in internal medicine clinics in Spain and highlight the multisystemic nature and high prevalence of this entity&#46; Specific internal medicine clinics dedicated to treating osteoporosis&#44; together with a medical record that is oriented to this entity which takes these clinical and demographic characteristics and adherence to clinical guidelines into account&#44; are an appropriate place for the care of these patients&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interest</span><p id="par0230" class="elsevierStylePara elsevierViewall">The authors declare that they do not have any conflicts of interest&#46;</p></span></span>"
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          "titulo" => "Resumen"
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          "titulo" => "Palabras clave"
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          "titulo" => "Introduction"
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          "titulo" => "Materials and methods"
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              "titulo" => "Statistical analysis"
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              "titulo" => "Ethical considerations"
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    "fechaRecibido" => "2020-02-01"
    "fechaAceptado" => "2020-06-05"
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            0 => "Osteoporosis"
            1 => "Internal medicine"
            2 => "Bone mineral density"
            3 => "Fractures"
            4 => "Comorbidities"
            5 => "Osteoporosis profile"
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            0 => "Osteoporosis"
            1 => "Medicina interna"
            2 => "Densidad mineral &#243;sea"
            3 => "Fracturas"
            4 => "Comorbilidades"
            5 => "Perfil osteoporosis"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Osteoporosis is considered a generalised skeletal disorder in which there is impaired bone resistance&#44; which predisposes the individual to a greater risk of fracture&#46; The aim of this cross-sectional study was to collect and present data on the main clinical characteristics of patients who consult medical internists in Spain&#46; Understanding these characteristics can help in implementing action plans to improve these patients&#8217; care more effectively and efficiently&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Through an analysis of the Osteoporosis in Internal Medicine &#40;OSTEOMED&#41; registry&#44; this study presents the main clinical characteristics of patients with osteoporosis who attended internal medicine consultations in 23 Spanish hospital centres between 2012 and 2017&#46; We analysed the reasons for the consultations&#44; the densitometric values&#44; the presence of comorbidities&#44; the prescribed treatment and other lifestyle-related factors&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In total&#44; 2024 patients with osteoporosis were assessed &#40;89&#46;87&#37; women&#44; 10&#46;13&#37; men&#41;&#46; The patients&#8217; mean age was 64&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;1 years &#40;women&#44; 64&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;5 years&#59; men&#44; 61&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;2 years&#41;&#46; There was no significant difference between the sexes in their history of recent falls &#40;9&#46;1&#37; and 6&#46;7&#37;&#41;&#59; however&#44; there were significant differences in the daily intake of calcium from milk products &#40;553&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>332&#46;6<span class="elsevierStyleHsp" style=""></span>mg for women vs&#46; 450&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>303&#46;3<span class="elsevierStyleHsp" style=""></span>mg for men&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; and in the secondary causes of osteoporosis &#40;13&#37; of men vs&#46; 6&#46;5&#37; of women&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; In the sample&#44; there were 404 fractures &#40;20&#37;&#41;&#44; with a notable number of confirmed vertebral fractures &#40;17&#46;2&#37;&#44; 35&#46;6&#37; in men vs&#46; 15&#46;2&#37; in women&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; A large portion of the patients did not undergo the indicated treatment and presented low levels of physical activity and sun exposure&#46; A significant percentage of the patients presented associated comorbidities&#44; the most common of which were hypertension &#40;32&#37;&#41; and dyslipidaemia &#40;28&#37;&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">These results define the profile of patients with osteoporosis who attend internal medicine consultations in Spain&#46; The results also show the multisystemic character of this condition&#44; which&#44; along with its high prevalence&#44; determine that the specific internal medicine consultations dedicated to managing the condition are the appropriate place for caring for these patients&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background and objectives"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material and methods"
          ]
          2 => array:2 [
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            "titulo" => "Results"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La osteoporosis se considera un trastorno generalizado del esqueleto en el que existe una alteraci&#243;n de la resistencia &#243;sea que predispone a la persona a un mayor riesgo de fractura&#46; Este estudio transversal pretende recoger y presentar las principales caracter&#237;sticas cl&#237;nicas de los pacientes que acuden a la consulta de los m&#233;dicos internistas en Espa&#241;a&#46; Conocer estas caracter&#237;sticas podr&#237;a facilitar la puesta en marcha de planes de actuaci&#243;n para mejorar la atenci&#243;n de estos pacientes de manera m&#225;s eficaz y eficiente&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A trav&#233;s del an&#225;lisis del registro OSTEOMED &#40;Osteoporosis en Medicina Interna&#41;&#44; este trabajo presenta las principales caracter&#237;sticas cl&#237;nicas de los pacientes con osteoporosis que acudieron a las consultas de Medicina Interna en 23 centros hospitalarios espa&#241;oles entre 2012 y 2017&#46; Se han analizado los motivos de consulta&#44; los valores densitom&#233;tricos&#44; la presencia de comorbilidades&#44; el tratamiento prescrito y otros factores relacionados con el estilo de vida&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En total se evalu&#243; a 2&#46;024 pacientes con osteoporosis &#40;89&#44;87&#37; mujeres&#44; 10&#44;13&#37; hombres&#41;&#46; La edad media de los pacientes fue de 64&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;1 a&#241;os &#40;mujeres&#44; 64&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44;5 a&#241;os&#59; hombres&#44; 61&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#44;2 a&#241;os&#41;&#46; No hubo diferencia entre sexos en la historia de ca&#237;das recientes &#40;9&#44;1-6&#44;7&#37;&#41;&#44; mientras que s&#237; se apreci&#243; en la ingesta diaria de calcio de l&#225;cteos &#40;553&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>332&#44;6<span class="elsevierStyleHsp" style=""></span>mg en mujeres vs&#46; 450&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>303&#44;3<span class="elsevierStyleHsp" style=""></span>mg en hombres&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y en causas secundarias de osteoporosis &#40;13&#37; de hombres vs&#46; 6&#44;5&#37; de mujeres&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; En la muestra se observaron un total de 404 fracturas &#40;20&#37;&#41;&#44; destacando el n&#250;mero de fracturas vertebrales confirmadas &#40;17&#44;2&#37;&#44; 35&#44;6&#37; en hombres vs&#46; 15&#44;2&#37; de las mujeres&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Una gran parte de los pacientes no recib&#237;a el tratamiento indicado y presentaba bajos niveles de actividad f&#237;sica y exposici&#243;n solar&#46; Un porcentaje importante de pacientes present&#243; comorbilidades asociadas&#44; siendo las m&#225;s frecuentes la hipertensi&#243;n &#40;32&#37;&#41; y la dislipidemia &#40;28&#37;&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estos resultados definen el perfil del paciente con osteoporosis que acude a la consulta de Medicina Interna en Espa&#241;a&#46; Adem&#225;s&#44; ponen de manifiesto el car&#225;cter multisist&#233;mico de esta entidad que junto con su elevada prevalencia determinan que las consultas espec&#237;ficas de Medicina Interna dedicadas a su manejo son el lugar adecuado para la atenci&#243;n de estos pacientes&#46;</p></span>"
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            "titulo" => "Material y m&#233;todos"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">The remaining members of the OSTEOMED Group are listed in <a class="elsevierStyleCrossRef" href="#sec0055">Appendix A</a>&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Bl&#225;zquez Cabrera JA&#44; Sosa Henriquez M&#44; Diaz-Curiel M&#44; S&#225;nchez Molini P&#44; Arranz Garcia F&#44; Montoya MJ&#44; et al&#46; Perfil de los pacientes que acuden al m&#233;dico internista para valoraci&#243;n de osteoporosis&#58; registro OSTEOMED&#46; Rev Clin Esp&#46; 2021&#59;221&#58;9&#8211;17&#46;</p>"
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            "apendice" => "<p id="par0235" class="elsevierStylePara elsevierViewall">Mar&#237;a Jos&#233; Amerigo &#40;Hospital Cl&#237;nico San Carlos&#41;&#44; Amalia Navarro &#40;Hospital Universitario Albacete&#41;&#44; Mar&#237;a Jes&#250;s Moro &#40;Hospital Infanta Sof&#237;a&#41;&#44; Jos&#233; Mar&#237;a Aguado Caballero &#40;Hospital La Moraleja&#41;&#44; Dolors Armengol Sucarrats &#40;Hospital de Terrassa&#41;&#44; Mar&#237;a Luz Calero Bernal &#40;Hospital Virgen del Roc&#237;o&#41;&#44; Juan Carlos Cobeta &#40;Hospital Ennet Lluch&#41;&#44; Rafael Cotos Canca &#40;Hospital San Carlos&#41;&#44; Bego&#241;a de Escalante Yanguas &#40;Hospital Lozano Blesa&#41;&#44; Nerea Hern&#225;ndez de Sosa &#40;Hospital Santa Creu y San Pablo&#41;&#44; Jos&#233; Luis Hern&#225;ndez &#40;Hospital Marqu&#233;s de Valdecilla&#41;&#44; Julia Jare&#241;o Chaumel &#40;Hospital San Carlos&#41;&#44; M&#46; &#193;ngeles V&#225;zquez G&#243;mez&#44; M&#46; Jos&#233; Miranda Garc&#237;a&#44; Mercedes Giner Garc&#237;a&#44; Cristina Miranda D&#237;az &#40;Hospital Virgen Macarena&#41;&#44; Antonio Pascual Vergara &#40;Hospital Serran&#237;a de Ronda&#41;&#44; Francisco Javier Rodero Hern&#225;ndez &#40;Hospital General de la Defensa Zaragoza&#41;&#44; Raimundo Tirado Miranda &#40;Hospital Infanta Margarita de Cabra&#41;&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Members of the OSTEOMED Group"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Data are shown as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation for continuous variables and as number of subjects and percentages for categorical variables&#46; Significant differences are indicated in bold&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">BMI&#58; body mass index&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">All&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Women&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Men&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value between sexes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Height &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">156&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">155&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">168&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Weight &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;956&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wingspan &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">161&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">159&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">175&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age of menarche &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age of menopause &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Calcium from dairy products &#40;mg&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">544&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>331&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">553&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>332&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">450&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>303&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Previous bone densitometry&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">348 &#40;17&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">328 &#40;16&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;&#60;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suffered a recent fall&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">179 &#40;8&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">164 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;6&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;398&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspected secondary osteoporosis&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">146 &#40;7&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117 &#40;6&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Main descriptive data of the cohort in the first visit&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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        "detalles" => array:1 [
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            "identificador" => "at2"
            "detalle" => "Table "
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        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Data are shown as number of subjects and percentage&#46; Significant differences are indicated in bold&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">All&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Men&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value between sexes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Family medical history&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">115 &#40;5&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102 &#40;88&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;11&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;788&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Early menopause&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">122 &#40;6&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">122 &#40;6&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;876&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Back pain or kyphosis&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">198 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">182 &#40;91&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;379&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Confirmed vertebral fractures&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">349 &#40;17&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">276 &#40;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-vertebral fractures&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">172 &#40;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;180&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atypical fractures&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;549&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Corticosteroid treatment&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65 &#40;3&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;76&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;13&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Breast cancer treatment&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">209 &#40;10&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">209 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prostate cancer treatment&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;0&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;070&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypogonadism &#40;excluding early menopause&#41;&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;0&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspected secondary osteoporosis&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">146 &#40;7&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117 &#40;80&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;19&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Follow-up or monitoring of osteoporosis&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">126 &#40;6&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118 &#40;93&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;6&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;372&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">Musculoskeletal pain&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Moderate</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">His&#47;her work entails physical effort&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">He&#47;she walks to work&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">He&#47;she goes up and down stairs actively&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#46;684&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Diabetes mellitus&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Hypothyroidism&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Hyperthyroidism&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;980&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Primary hyperparathyroidism&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">75 &#40;3&#46;71&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Nephrolithiasis&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;130&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Idiopathic hypercalciuria&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;216&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Kidney failure&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">COPD&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Interstitial lung disease&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;062&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">PMR&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Temporal arteritis&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Rheumatoid arthritis&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;&#60;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">12 &#40;85&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;410&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Breast cancer&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;0&#46;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Crohn&#39;s disease&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Consensus development conference&#58; prophylaxis and treatment of osteoporosis"
                    ]
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                    0 => array:2 [
                      "doi" => "10.1016/0002-9343(91)90512-V"
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                        "tituloSerie" => "Am J Med"
                        "fecha" => "1991"
                        "volumen" => "90"
                        "paginaInicial" => "107"
                        "paginaFinal" => "110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1986575"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
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              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of osteoporotic fractures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Johnell"
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                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1007/s00198-004-1702-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "Osteoporos Int"
                        "fecha" => "2005"
                        "volumen" => "16"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "S3"
                        "paginaFinal" => "S7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15365697"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osteoporosis&#58; the evolution of a diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Lorentzon"
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                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/joim.12369"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intern Med"
                        "fecha" => "2015"
                        "volumen" => "277"
                        "paginaInicial" => "650"
                        "paginaFinal" => "661"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25832448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patient preferences for osteoporosis in Spain&#58; a discrete choice experiment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Darba"
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                            2 => "L&#46; Kaskens"
                            3 => "M&#46;A&#46; Balbona"
                            4 => "A&#46; Carbonell"
                            5 => "P&#46; Cavero"
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                        ]
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                        "fecha" => "2011"
                        "volumen" => "22"
                        "paginaInicial" => "1947"
                        "paginaFinal" => "1954"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20838770"
                            "web" => "Medline"
                          ]
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                  ]
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              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osteoporosis in the European Union&#58; a compendium of country-specific reports"
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                            4 => "C&#46; Cooper"
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                          ]
                        ]
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                        "tituloSerie" => "Arch Osteoporos"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "137"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24113838"
                            "web" => "Medline"
                          ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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                        "tituloSerie" => "Lancet"
                        "fecha" => "2006"
                        "volumen" => "367"
                        "paginaInicial" => "2010"
                        "paginaFinal" => "2018"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16782492"
                            "web" => "Medline"
                          ]
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              "referencia" => array:1 [
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                        "fecha" => "2002"
                        "volumen" => "359"
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                        "paginaFinal" => "1767"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12049882"
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                          ]
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              "identificador" => "bib0040"
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                    0 => array:2 [
                      "titulo" => "An overview and management of osteoporosis"
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                        0 => array:2 [
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                        "fecha" => "2017"
                        "volumen" => "4"
                        "paginaInicial" => "46"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
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                          ]
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                          "autores" => array:3 [
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                        "paginaInicial" => "561"
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                        "link" => array:1 [
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                    0 => array:2 [
                      "doi" => "10.1007/BF01622200"
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                        "paginaFinal" => "381"
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                0 => array:2 [
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                            0 => "F&#46; Cosman"
                            1 => "S&#46;J&#46; de Beur"
                            2 => "M&#46;S&#46; LeBoff"
                            3 => "E&#46;M&#46; Lewiecki"
                            4 => "B&#46; Tanner"
                            5 => "S&#46; Randall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00198-014-2794-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Osteoporos Int"
                        "fecha" => "2014"
                        "volumen" => "25"
                        "paginaInicial" => "2359"
                        "paginaFinal" => "2381"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25182228"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "World Medical Association Declaration of Helsinki&#58; ethical principles for medical research involving human subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "World Medical Association"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2013.281053"
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                        "tituloSerie" => "JAMA"
                        "fecha" => "2013"
                        "volumen" => "310"
                        "paginaInicial" => "2191"
                        "paginaFinal" => "2194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24141714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global recommendations on physical activity for health"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "World Health Organization"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "fecha" => "2010"
                        "editorial" => "World Health Organization"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Denosumab for prevention of fractures in postmenopausal women with osteoporosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;R&#46; Cummings"
                            1 => "J&#46; San Martin"
                            2 => "M&#46;R&#46; McClung"
                            3 => "E&#46;S&#46; Siris"
                            4 => "R&#46; Eastell"
                            5 => "I&#46;R&#46; Reid"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa0809493"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2009"
                        "volumen" => "361"
                        "paginaInicial" => "756"
                        "paginaFinal" => "765"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19671655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Romosozumab treatment in postmenopausal women with osteoporosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Cosman"
                            1 => "D&#46;B&#46; Crittenden"
                            2 => "J&#46;D&#46; Adachi"
                            3 => "N&#46; Binkley"
                            4 => "E&#46; Czerwinski"
                            5 => "S&#46; Ferrari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1607948"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2016"
                        "volumen" => "375"
                        "paginaInicial" => "1532"
                        "paginaFinal" => "1543"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27641143"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The influence of lifestyle&#44; diet&#44; and reproductive history on age at natural menopause in Spain&#58; analysis from the EPIC-Spain sub-cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Lujan-Barroso"
                            1 => "K&#46; Gibert"
                            2 => "M&#46; Obon-Santacana"
                            3 => "M&#46;D&#46; Chirlaque"
                            4 => "M&#46;J&#46; Sanchez"
                            5 => "N&#46; Larra&#241;aga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ajhb.23181"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Hum Biol"
                        "fecha" => "2018"
                        "volumen" => "30"
                        "paginaInicial" => "e23181"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30251288"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predicci&#243;n de la ingesta total de calcio a trav&#233;s del consumo de l&#225;cteos en la poblaci&#243;n adulta de Espa&#241;a Estudio INDICAD 2001"
                      "autores" => array:1 [
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                          "autores" => array:4 [
                            0 => "P&#46; Orozco L&#243;pez"
                            1 => "M&#46; Zwart Salmer&#243;n"
                            2 => "E&#46; Vilert Garrofa"
                            3 => "C&#46; Olmos Dom&#237;nguez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1157/13059168"
                      "Revista" => array:6 [
                        "tituloSerie" => "Aten Primaria"
                        "fecha" => "2004"
                        "volumen" => "33"
                        "paginaInicial" => "237"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15033092"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calcium intake from dairy and non-dairy products in early postmenopausal women population of Albacete"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Navarro"
                            1 => "J&#46;A&#46; Bl&#225;zquez"
                            2 => "M&#46; Ch&#225;fer"
                            3 => "A&#46; Navarro Martinez"
                            4 => "C&#46; Andres Fernandez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "27th World Congress of Internal Medicine"
                        "conferencia" => "September 26th&#8211;october 1st&#44; Granada"
                        "serieFecha" => "2004"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diet and exercise&#58; a match made in bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;M&#46;E&#46; Willems"
                            1 => "E&#46;G&#46;H&#46;M&#46; van den heuvel"
                            2 => "R&#46;J&#46;W&#46; Schoemaker"
                            3 => "J&#46; Klein-Nulend"
                            4 => "A&#46;D&#46; Bakker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11914-017-0406-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Osteoporos Rep"
                        "fecha" => "2017"
                        "volumen" => "15"
                        "paginaInicial" => "555"
                        "paginaFinal" => "563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29098573"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exercise is the real polypill"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Fiuza-Luces"
                            1 => "N&#46; Garatachea"
                            2 => "N&#46;A&#46; Berger"
                            3 => "A&#46; Lucia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/physiol.00019.2013"
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                        "tituloSerie" => "Physiology &#40;Bethesda&#41;"
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                        "volumen" => "28"
                        "paginaInicial" => "330"
                        "paginaFinal" => "358"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vitamin D and calcium supplements for preventing fractures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Jin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2018.3892"
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2018"
                        "volumen" => "319"
                        "paginaInicial" => "1630"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29677304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osteoporosis en el var&#243;n"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;J&#46; Moro-&#193;lvarez"
                            1 => "J&#46;A&#46; Bl&#225;zquez Cabrera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rce.2009.11.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Clin Esp"
                        "fecha" => "2010"
                        "volumen" => "210"
                        "paginaInicial" => "342"
                        "paginaFinal" => "349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20546723"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical practice&#46; Postmenopausal osteoporosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;M&#46; Black"
                            1 => "C&#46;J&#46; Rosen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMcp1513724"
                      "Revista" => array:6 [
                        "tituloSerie" => "New Engl J Med"
                        "fecha" => "2016"
                        "volumen" => "374"
                        "paginaInicial" => "254"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26789873"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osteoporosis treatment&#58; recent developments and ongoing challenges"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Khosla"
                            1 => "L&#46;C&#46; Hofbauer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-8587(17)30188-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Diabetes Endocrinol"
                        "fecha" => "2017"
                        "volumen" => "5"
                        "paginaInicial" => "898"
                        "paginaFinal" => "907"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28689769"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Specialization&#44; subspecialization&#44; and subsubspecialization in internal medicine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;K&#46; Cassel"
                            1 => "D&#46;B&#46; Reuben"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMsb1012647"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2011"
                        "volumen" => "364"
                        "paginaInicial" => "1169"
                        "paginaFinal" => "1173"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21428774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eumatolog&#237;a y osteoporosis &#40;RETOSS&#41;&#58; osteoporosis posmenop&#225;usica en la consulta de reumatolog&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Bernad"
                            1 => "C&#46;M&#46; Gonz&#225;lez"
                            2 => "M&#46; Fernandez Prada"
                            3 => "J&#46; Fernandez Campillo"
                            4 => "R&#46; Maeso Martin"
                            5 => "M&#46;V&#46; Garc&#237;a Puentes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMsb1012647"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2011"
                        "volumen" => "7"
                        "paginaInicial" => "13"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
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Vol. 221. Issue 1.
Pages 9-17 (January 2021)
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Vol. 221. Issue 1.
Pages 9-17 (January 2021)
Original article
Profile of patients who consult with internists for an osteoporosis assessment: The OSTEOMED registry
Perfil de los pacientes que acuden al médico internista para valoración de osteoporosis: registro OSTEOMED
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J.A. Blázquez Cabreraa, M. Sosa Henriquezb, M. Diaz-Curielc, P. Sánchez Molinid, F. Arranz Garciae, M.J. Montoyaf, J. Filgueirag, J.M. Olmosh, M.B. Coco-Martíni, J.L. Pérez Castrillónj,
Corresponding author
uvacastrv@gmail.com

Corresponding author.
, on behalf of the OSTEOMED Group
a Servicio de Medicina Interna, Hospital Universitario Albacete, Albacete, Spain
b Servicio de Medicina Interna, Hospital Universitario Insular, Las Palmas de Gran Canaria, Las Palmas, Spain
c Servicio de Medicina Interna, Fundación Jiménez Díaz, Madrid, Spain
d Servicio de Medicina Interna, Hospital de la Princesa, Madrid, Spain
e Servicio de Medicina Interna, Hospital Clínico San Carlos, Madrid, Spain
f Servicio de Medicina Interna, Hospital Universitario Virgen Macarena, Sevilla, Spain
g Servicio de Medicina Interna, Hospital Universitario Gregorio Marañón, Madrid, Spain
h Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain
i Grupo de Investigación en Neurociencias Clínicas Aplicadas, Universidad de Valladolid, Valladolid, Spain
j Servicio de Medicina Interna, Hospital Universitario Río Hortega, Valladolid, Spain
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Tables (5)
Table 1. Main descriptive data of the cohort in the first visit.
Table 2. Reason for first consultation with an internal medicine specialist.
Table 3. Lifestyle characteristics of the cohort.
Table 4. Patients in prior treatment.
Table 5. Patients in the cohort with associated comorbidities.
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Abstract
Background and objectives

Osteoporosis is considered a generalised skeletal disorder in which there is impaired bone resistance, which predisposes the individual to a greater risk of fracture. The aim of this cross-sectional study was to collect and present data on the main clinical characteristics of patients who consult medical internists in Spain. Understanding these characteristics can help in implementing action plans to improve these patients’ care more effectively and efficiently.

Material and methods

Through an analysis of the Osteoporosis in Internal Medicine (OSTEOMED) registry, this study presents the main clinical characteristics of patients with osteoporosis who attended internal medicine consultations in 23 Spanish hospital centres between 2012 and 2017. We analysed the reasons for the consultations, the densitometric values, the presence of comorbidities, the prescribed treatment and other lifestyle-related factors.

Results

In total, 2024 patients with osteoporosis were assessed (89.87% women, 10.13% men). The patients’ mean age was 64.1±12.1 years (women, 64.7±11.5 years; men, 61.2±14.2 years). There was no significant difference between the sexes in their history of recent falls (9.1% and 6.7%); however, there were significant differences in the daily intake of calcium from milk products (553.8±332.6mg for women vs. 450.2±303.3mg for men; p<.001) and in the secondary causes of osteoporosis (13% of men vs. 6.5% of women; p<.001). In the sample, there were 404 fractures (20%), with a notable number of confirmed vertebral fractures (17.2%, 35.6% in men vs. 15.2% in women; p<.001). A large portion of the patients did not undergo the indicated treatment and presented low levels of physical activity and sun exposure. A significant percentage of the patients presented associated comorbidities, the most common of which were hypertension (32%) and dyslipidaemia (28%).

Conclusions

These results define the profile of patients with osteoporosis who attend internal medicine consultations in Spain. The results also show the multisystemic character of this condition, which, along with its high prevalence, determine that the specific internal medicine consultations dedicated to managing the condition are the appropriate place for caring for these patients.

Keywords:
Osteoporosis
Internal medicine
Bone mineral density
Fractures
Comorbidities
Osteoporosis profile
Resumen
Antecedentes y objetivo

La osteoporosis se considera un trastorno generalizado del esqueleto en el que existe una alteración de la resistencia ósea que predispone a la persona a un mayor riesgo de fractura. Este estudio transversal pretende recoger y presentar las principales características clínicas de los pacientes que acuden a la consulta de los médicos internistas en España. Conocer estas características podría facilitar la puesta en marcha de planes de actuación para mejorar la atención de estos pacientes de manera más eficaz y eficiente.

Material y métodos

A través del análisis del registro OSTEOMED (Osteoporosis en Medicina Interna), este trabajo presenta las principales características clínicas de los pacientes con osteoporosis que acudieron a las consultas de Medicina Interna en 23 centros hospitalarios españoles entre 2012 y 2017. Se han analizado los motivos de consulta, los valores densitométricos, la presencia de comorbilidades, el tratamiento prescrito y otros factores relacionados con el estilo de vida.

Resultados

En total se evaluó a 2.024 pacientes con osteoporosis (89,87% mujeres, 10,13% hombres). La edad media de los pacientes fue de 64,1±12,1 años (mujeres, 64,7±11,5 años; hombres, 61,2±14,2 años). No hubo diferencia entre sexos en la historia de caídas recientes (9,1-6,7%), mientras que sí se apreció en la ingesta diaria de calcio de lácteos (553,8±332,6mg en mujeres vs. 450,2±303,3mg en hombres; p<0,001) y en causas secundarias de osteoporosis (13% de hombres vs. 6,5% de mujeres; p<0,001). En la muestra se observaron un total de 404 fracturas (20%), destacando el número de fracturas vertebrales confirmadas (17,2%, 35,6% en hombres vs. 15,2% de las mujeres; p<0,001). Una gran parte de los pacientes no recibía el tratamiento indicado y presentaba bajos niveles de actividad física y exposición solar. Un porcentaje importante de pacientes presentó comorbilidades asociadas, siendo las más frecuentes la hipertensión (32%) y la dislipidemia (28%).

Conclusiones

Estos resultados definen el perfil del paciente con osteoporosis que acude a la consulta de Medicina Interna en España. Además, ponen de manifiesto el carácter multisistémico de esta entidad que junto con su elevada prevalencia determinan que las consultas específicas de Medicina Interna dedicadas a su manejo son el lugar adecuado para la atención de estos pacientes.

Palabras clave:
Osteoporosis
Medicina interna
Densidad mineral ósea
Fracturas
Comorbilidades
Perfil osteoporosis

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