The rise and fall of mpox | Revista Clínica Española

array:24 ["pii" => "S2254887422000911" "issn" => "22548874" "doi" => "10.1016/j.rceng.2022.10.002" "estado" => "S300" "fechaPublicacion" => "2023-01-01" "aid" => "2063" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)" "copyrightAnyo" => "2022" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "edi" "cita" => "Rev Clin Esp. 2023;223:60-1" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0014256522001412" "issn" => "00142565" "doi" => "10.1016/j.rce.2022.10.005" "estado" => "S300" "fechaPublicacion" => "2023-01-01" "aid" => "2063" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "edi" "cita" => "Rev Clin Esp. 2023;223:60-1" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "Editorial" "titulo" => "El ascenso y la caída del virus de la viruela del mono" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "60" "paginaFinal" => "61" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The rise and fall of mpox" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Ena, R.P. Wenzel" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Ena" ] 1 => array:2 [ "nombre" => "R.P." "apellidos" => "Wenzel" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2254887422000911" "doi" => "10.1016/j.rceng.2022.10.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887422000911?idApp=WRCEE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256522001412?idApp=WRCEE" "url" => "/00142565/0000022300000001/v1_202301050621/S0014256522001412/v1_202301050621/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2254887422000534" "issn" => "22548874" "doi" => "10.1016/j.rceng.2022.03.007" "estado" => "S300" "fechaPublicacion" => "2023-01-01" "aid" => "2031" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Rev Clin Esp. 2023;223:62-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Correspondence" "titulo" => "Another way to approach post-COVID syndrome. From functionality to the symptoms" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "62" "paginaFinal" => "64" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Otra forma de abordar el síndrome pos-COVID. De la funcionalidad al síntoma" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1449 "Ancho" => 2516 "Tamanyo" => 494673 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0165" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Multidisciplinary follow-up protocol diagram for patients with suspected PCC from the San Juan de Alicante Health Department (Alicante). 1 min STST: 1 min Sit-To-Stand Test; GLIM: Global Leadership Initiative on Malnutrition criteria; mMRC: Modified Medical Research Council Scale; NEUR: neurology; PCC: post-COVID condition; PCFS: Post-COVID-19 Functional Scale; PFT: pulmonary function test; PSY: psychiatry; PULM: pulmonology; REHAB: rehabilitation; RHU: rheumatology; SC: systemic corticosteroids; X-ray: simple radiography." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. Giner-Galvañ, M.L. Asensio-Tomás, D. Díez-Herrero, P. Wikman-Jorgensen" "autores" => array:4 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Giner-Galvañ" ] 1 => array:2 [ "nombre" => "M.L." "apellidos" => "Asensio-Tomás" ] 2 => array:2 [ "nombre" => "D." "apellidos" => "Díez-Herrero" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Wikman-Jorgensen" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0014256522000728" "doi" => "10.1016/j.rce.2022.03.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256522000728?idApp=WRCEE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887422000534?idApp=WRCEE" "url" => "/22548874/0000022300000001/v1_202301110738/S2254887422000534/v1_202301110738/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2254887422001084" "issn" => "22548874" "doi" => "10.1016/j.rceng.2022.11.002" "estado" => "S300" "fechaPublicacion" => "2023-01-01" "aid" => "2067" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "edi" "cita" => "Rev Clin Esp. 2023;223:58-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "Editorial" "titulo" => "Ethical consultancy. Towards an applicable and sustainable Spanish model" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "58" "paginaFinal" => "59" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La consultoría ética. Hacia un modelo Español aplicable y sostenible" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Altisent, J.J. Fins" "autores" => array:2 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Altisent" ] 1 => array:2 [ "nombre" => "J.J." "apellidos" => "Fins" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S001425652200145X" "doi" => "10.1016/j.rce.2022.11.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S001425652200145X?idApp=WRCEE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887422001084?idApp=WRCEE" "url" => "/22548874/0000022300000001/v1_202301110738/S2254887422001084/v1_202301110738/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Editorial" "titulo" => "The rise and fall of mpox" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "60" "paginaFinal" => "61" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Ena, R.P. Wenzel" "autores" => array:2 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Ena" "email" => array:1 [ 0 => "ena_jav@gva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "R.P." "apellidos" => "Wenzel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departmento de Medicina Interna, Hospital Marina Baixa, Villajoyosa (Alicante), Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Internal Medicine, Virginia Commonwealth University Health, Richmond, VA, USA" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El ascenso y la caída del virus de la viruela del mono" ] ] "textoCompleto" => "The World Health Organization (WHO) director-general declared the mpox outbreak a Public Health Emergency of International Concern on July 23, 2022. As of October 13, 2022, more than 72,000 confirmed cases of monkeypox had been reported across 82 nonendemic countries, with death reported in 28 cases<a class="elsevierStyleCrossRef" href="#bib0005">1</a>. The most affected countries have been the United States of America (27,096 cases (2 fatal)), Brazil (8521 cases (5 fatal)), Spain (7239 cases (2 fatal)), and France (4064 cases).The WHO implemented a coordinated international response and the measures taken have proven effective in slowing the pace of the outbreak in recent months<a class="elsevierStyleCrossRef" href="#bib0010">2</a>.At the beginning of the outbreak, some uncertainties included how exactly the infection was transmitted, how widespread it was likely to become, whether it was a different strain from what was known, and what the utility of a vaccine to mitigate transmission would be<a class="elsevierStyleCrossRef" href="#bib0015">3</a>. Early reports describing the epidemiology of mpox indicated that transmission occurred through skin-to-skin contact with infectious lesions. The highest-risk population was determined to be men who acquired the infection through sexual or intimate contact with other men<a class="elsevierStyleCrossRefs" href="#bib0020">4,5</a>. Having multiple sexual partners was found to be a risk factor for the disease; coinfection with other sexually transmitted diseases was noted in approximately 25% of patients and coinfection with HIV in as many as 41%.Fewer than 5% of cases have been reported among females, pregnant women, children, and healthcare workers after a percutaneous needle injury.Molecular analysis of the ongoing 2022 multi-country outbreak comprising the human west African Mpox-1A clade revealed three newly classified lineages (A.1, A.1.1, A.2) and a B1 lineage that emerged in Europe on March 2, 2022<a class="elsevierStyleCrossRef" href="#bib0030">6</a>. These data suggest that several factors have been involved in the current outbreak dynamics, including the cessation of smallpox vaccination and the spreading of the infection among particular networks.The United States Food and Drug Administration (FDA) approved the JYNNEOS (Modified Vaccinia Ankara Vaccine, Bavarian Nordic) smallpox vaccine as a potentially helpful vaccine for mpox. Given that the live virus does not replicate in mammalian cells, it is considered safer than the conventional smallpox vaccine.In May 2022, the United States started distributing the JYNNEOS vaccine as postexposure prophylaxis for individuals with known exposure to mpox. In addition, JYNNEOS was also offered to individuals receiving pre-exposure prophylaxis (PrEP) for HIV/AIDS. A preliminary analysis of JYNNEOS showed an efficacy of 70% for subjects who had received their first dose ≥14 days earlier and an effectiveness of 98% for those who had received their second dose ≥14 days earlier<a class="elsevierStyleCrossRef" href="#bib0035">7</a>.Tecovirimat is the only drug approved by the European Medicines Agency for the treatment of mpox<a class="elsevierStyleCrossRef" href="#bib0040">8</a>. Tecovirimat is administrated at a daily dosage of 1200 mg together with a meal. The efficacy of tecovirimat for mpox in humans has been documented in small case series. The most common indication for tecovirimat was mpox in patients with immunosuppression due to underlying conditions or with severe symptomatic disease-causing tonsillar edema and odynophagia, eyelid lesions, or severe rectal pain<a class="elsevierStyleCrossRefs" href="#bib0045">9–11</a>. Tecovirimat showed a good safety profile in these small case series, with no significant side effects reported. Clinical improvement coincided with a >2 log drop in monkeypox viremia within seven days<a class="elsevierStyleCrossRef" href="#bib0055">11</a>.Uncertainties remain, including the possibility of the virus establishing an animal reservoir outside of Africa, the duration of immunity after one-dose or two-dose vaccine schedules, more precisely the various behaviors in sexual transmission, and understanding alternative transmission pathways.In summary, we should be prepared to face outbreaks of zoonotic origin since they are a natural part of life on a small planet shared with multiple non-human species. Controlling the current epidemic requires a coordinated effort among countries to implement infection control measures. Fortunately, airborne transmission is not prominent. The key factors behind the current decline in cases have included establishing trust with the at-risk population, encouraging them to change their behaviors and accept a vaccination program, and the availability of active and safe antiviral therapy to treat severe cases." "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The WHO declaration of monkeypox as a global health emergency" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.B. Nuzzo" 1 => "L.L. Borio" 2 => "L.O. Gostin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2022.12513" "Revista" => array:7 [ "tituloSerie" => "JAMA" "fecha" => "2022" "volumen" => "328" "numero" => "7" "paginaInicial" => "615" "paginaFinal" => "617" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35895041" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Centers for Disease Control and Prevention (CDC). Confirmed and suspected cases by country as of October 13 2022. Available from: <a target="_blank" href="https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html">https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html</a>. (Last access: 21 October 2022)." ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Monkeypox: a poxvirus emerges once again" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Ena" 1 => "R.P. Wenzel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rceng.2022.05.001" "Revista" => array:6 [ "tituloSerie" => "Rev Clin Esp (Barc)" "fecha" => "2022" "volumen" => "222" "paginaInicial" => "504" "paginaFinal" => "505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35750596" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Monkeypox virus infection in humans across 16 countries — April-June 2022" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.P. Thornhill" 1 => "S. Barkati" 2 => "S. Walmsley" 3 => "J. Rockstroh" 4 => "A. Antinori" 5 => "L.B. Harrison" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa2207323" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2022" "volumen" => "387" "paginaInicial" => "679" "paginaFinal" => "691" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35866746" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features and management of human monkeypox: a retrospective observational study in the UK" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Adler" 1 => "S. Gould" 2 => "P. Hine" 3 => "L.B. Snell" 4 => "W. Wong" 5 => "C.F. Houlihan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1473-3099(22)00228-6" "Revista" => array:6 [ "tituloSerie" => "Lancet Infect Dis" "fecha" => "2022" "volumen" => "22" "paginaInicial" => "1153" "paginaFinal" => "1162" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35623380" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phylogenomic analysis of the monkeypox virus (MPXV) 2022 outbreak: emergence of a novel viral lineage?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Luna" 1 => "A.L. Ramírez" 2 => "M. Muñoz" 3 => "N. Ballesteros" 4 => "L.H. Patiño" 5 => "S.A. Castañeda" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tmaid.2022.102402" "Revista" => array:4 [ "tituloSerie" => "Travel Med Infect Dis" "fecha" => "2022" "volumen" => "49" "paginaInicial" => "102402" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of monkeypox among unvaccinated persons compared with persons receiving ≥1 JYNNEOS vaccine dose — 32 U.S. Jurisdictions, July 31-September 3, 2022" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.B. Payne" 1 => "L.C. Ray" 2 => "K.J. Kugeler" 3 => "A. Fothergill" 4 => "E.B. White" 5 => "M. Canning" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.15585/mmwr.mm7140e3" "Revista" => array:7 [ "tituloSerie" => "MMWR Morb Mortal Wkly Rep" "fecha" => "2022" "volumen" => "71" "numero" => "October (40)" "paginaInicial" => "1278" "paginaFinal" => "1282" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36201401" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "European Medicines Agency (EMA). Drug information on tecovirimat. Available from: <a target="_blank" href="https://www.ema.europa.eu/en/medicines/human/EPAR/tecovirimat-siga">https://www.ema.europa.eu/en/medicines/human/EPAR/tecovirimat-siga</a>. (Last access: 21 October 2022)." ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tecovirimat for the treatment of human monkeypox: an initial series from Massachusetts, United States" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.R. Matias" 1 => "J.M. Koshy" 2 => "E.H. Nagami" 3 => "V. Kovac" 4 => "L.R. Moeng" 5 => "E.S. Shenoy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ofid/ofac377" "Revista" => array:5 [ "tituloSerie" => "Open Forum Infect Dis" "fecha" => "2022" "volumen" => "9" "numero" => "July (8)" "paginaInicial" => "ofac377" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Monkeypox virus-associated severe proctitis treated with oral tecovirimat: a report of two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Lucar" 1 => "A. Roberts" 2 => "K.M. Saardi" 3 => "R. Yee" 4 => "M.O. Siegel" 5 => "T.N. Palmore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7326/L22-0300" "Revista" => array:3 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2022" "numero" => "August" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tecovirimat therapy for severe monkeypox infection: longitudinal assessment of viral titers and clinical response pattern—a first case-series experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Hermanussen" 1 => "I. Grewe" 2 => "H.T. Tang" 3 => "D. Nörz" 4 => "L.C. Bal" 5 => "S. Pfefferle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jmv.28181" "Revista" => array:3 [ "tituloSerie" => "J Med Virol" "fecha" => "2022" "numero" => "September" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22548874/0000022300000001/v1_202301110738/S2254887422000911/v1_202301110738/en/main.assets" "Apartado" => array:4 [ "identificador" => "72714" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Editorials" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22548874/0000022300000001/v1_202301110738/S2254887422000911/v1_202301110738/en/main.pdf?idApp=WRCEE&text.app=https://www.revclinesp.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887422000911?idApp=WRCEE"]

Revista Clínica Española

ISSN: 0014-2565

Revista Clínica Española, publicó su primer número en 1940 y es órgano de expresión de la Sociedad Española de Medicina Interna (SEMI).
La Revista hace suyos los objetivos de actualizar los conocimientos y facilitar la adquisición de los avances claves de la medicina interna aplicados a la clínica. Revista Clínica Española somete a una rigurosa revisión doble ciega los artículos que recibe en español o inglés. Publica 10 números al año fundamentalmente con originales, revisiones y documentos de consenso.

Indexada en:

Current Contents / Clinical Medicine , JCR / SCI-Expanded, Index Medicus / Medline y Excerpta Medica / EMBASE

Artículo

Opciones para acceder a los textos completos de la publicación Revista Clínica Española

Socio de la sociedad

Suscriptor

Contactar

Socio

Si es usted socio de FESEMI siga los siguientes pasos:

Diríjase desde aquí a la web de la >>>FESEMI<<< e inicie sesión mediante el formulario que se encuentra en la barra superior, pulsando sobre el candado.