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      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "The short-term prognostic value of C-reactive protein in elderly patients with acute heart failure"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El mejor conocimiento de la fisiopatolog&#237;a de la insuficiencia card&#237;aca ha conducido a la formulaci&#243;n secuencial de modelos patog&#233;nicos cardiorrenales&#44; hemodin&#225;micos y finalmente neurohormonales<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">1</span></a>&#46; Recientemente&#44; tambi&#233;n se ha considerado que la respuesta inflamatoria que conduce al da&#241;o endotelial desempe&#241;a un papel importante en la patogenia de este s&#237;ndrome<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">2&#44;3</span></a>&#44; como ocurre en otras enfermedades cardiovasculares<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Se considera que la prote&#237;na C reactiva &#40;PCR&#41;&#44; prote&#237;na plasm&#225;tica circulante sintetizada en los hepatocitos y en otros tejidos extrahep&#225;ticos en respuesta a la se&#241;alizaci&#243;n por la interleucina-6&#44; es un biomarcador cl&#225;sico de proceso agudo&#44; tanto de procesos inflamatorios como de da&#241;o tisular o infecci&#243;n<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">5</span></a>&#46; En pacientes con factores de riesgo cardiovascular la detecci&#243;n de altas concentraciones plasm&#225;ticas de PCR permite predecir el desarrollo de enfermedad card&#237;aca<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">6</span></a>&#59; asimismo&#44; ayuda a evaluar el pron&#243;stico en pacientes con disnea<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">7</span></a>&#44; cardiopat&#237;a isqu&#233;mica<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">8</span></a> o insuficiencia card&#237;aca cr&#243;nica estable<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">9</span></a>&#46; La insuficiencia card&#237;aca aguda &#40;ICA&#41; es un s&#237;ndrome cl&#237;nico con altas tasas de mortalidad y de reingreso hospitalario<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">10</span></a>&#46; Varios estudios se han centrado en intentar identificar biomarcadores f&#225;cilmente disponibles que&#44; bien solos o en combinaci&#243;n con datos demogr&#225;ficos&#44; cl&#237;nicos o electrocardiogr&#225;ficos&#44; puedan ayudar a predecir&#44; de la manera m&#225;s precisa posible&#44; el riesgo de muerte o reingreso hospitalario de los pacientes con ICA<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">11&#44;12</span></a>&#46; Aunque disponemos de datos sobre la validez de la PCR o PCR ultrasensible &#40;PCRus&#41; como predictores en estos pacientes&#44; hay que tener en cuenta que muchos datos derivan de suban&#225;lisis de ensayos cl&#237;nicos<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">13&#44;14</span></a>&#44; de estudios derivados de cohortes de pacientes j&#243;venes con insuficiencia card&#237;aca con fracci&#243;n de eyecci&#243;n reducida &#40;ICFER&#41;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">15&#44;16</span></a> y solo en algunos casos de estudios &#171;de la vida real&#187; en pacientes con insuficiencia card&#237;aca de cualquier causa o edad&#44; con resultados dispares<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">17-24</span></a>&#46; Es&#44; por lo tanto&#44; a&#250;n desconocido si determinar los niveles de PCR al ingreso a&#241;ade valor pron&#243;stico cuando la poblaci&#243;n con ICA analizada est&#225; constituida exclusivamente por ancianos&#46; Los pacientes de edad avanzada se caracterizan&#44; adem&#225;s de por una menor prevalencia de ICFER&#44; por presentar mayor n&#250;mero de comorbilidades cardiovasculares y no cardiovasculares&#44; por estar polimedicados y por poseer caracter&#237;sticas &#171;geri&#225;tricas&#187; espec&#237;ficas&#44; como la fragilidad&#44; el deterioro cognitivo o la discapacidad&#44; todos ellos elementos con una fuerte influencia pron&#243;stica&#44; superior a la de los hallazgos cl&#237;nicos cl&#225;sicos asociados a episodios de insuficiencia card&#237;aca o de ICA en particular<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">25</span></a>&#46; En este estudio&#44; nuestra intenci&#243;n es valorar si el an&#225;lisis de rutina de los niveles de PCR plasm&#225;tica en ancianos en el momento de ingreso hospitalario a causa de un episodio de ICA ayuda o no a predecir con mayor precisi&#243;n su riesgo de mortalidad a medio plazo &#40;3 meses&#41; o de reingreso&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todos</span><p id="par0015" class="elsevierStylePara elsevierViewall">Los datos de los pacientes se obtuvieron del Registro Nacional de Insuficiencia Card&#237;aca &#40;RICA&#41;&#44; confeccionado por miembros del Grupo de Trabajo en Insuficiencia Card&#237;aca de la Sociedad Espa&#241;ola de Medicina Interna&#46; El RICA es un registro multic&#233;ntrico&#44; prospectivo y de cohortes de pacientes ingresados por un episodio de descompensaci&#243;n de insuficiencia card&#237;aca &#40;tanto de novo como cr&#243;nica descompensada&#41; en los servicios de Medicina Interna de 52 hospitales de toda Espa&#241;a&#44; en su mayor&#237;a p&#250;blicos y con participaci&#243;n de algunos privados<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">26</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">En el registro se incluye a todos los pacientes de 50 o m&#225;s a&#241;os ingresados en dichos servicios de Medicina Interna&#44; cuyos s&#237;ntomas y signos en fase aguda son concordantes con los criterios actuales de la Sociedad Europea de Cardiolog&#237;a para el diagn&#243;stico de insuficiencia card&#237;aca<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">27</span></a>&#46; No se registran&#44; sin embargo&#44; los datos de los pacientes que fallecen por cualquier causa durante el ingreso &#237;ndice&#44; que quedan excluidos&#44; por lo tanto&#44; de futuros an&#225;lisis&#46; Despu&#233;s del ingreso &#237;ndice se lleva a cabo un seguimiento regular de los pacientes en el que se eval&#250;an su estado vital&#44; datos sobre nuevos ingresos e informaci&#243;n cl&#237;nica b&#225;sica&#46; A criterio de los m&#233;dicos que siguen a estos pacientes&#44; se pueden efectuar visitas no programadas&#46; Cuando los pacientes no acuden a las visitas de seguimiento&#44; se intenta contactar con ellos o sus familiares para determinar el motivo de las ausencias&#46; Todos los datos de ingreso y seguimiento son recogidos detalladamente a trav&#233;s de un sitio web protegido por contrase&#241;a &#40;<a id="intr0005" class="elsevierStyleInterRef" href="https://www.registrorica.org/">https&#58;&#47;&#47;www&#46;registrorica&#46;org&#47;</a>&#41;&#44; que aloja la base de datos principal&#59; estos datos son&#58; <span class="elsevierStyleItalic">a&#41;</span> sociodemogr&#225;ficos&#59; <span class="elsevierStyleItalic">b&#41;</span> historial m&#233;dico relacionado con la insuficiencia card&#237;aca &#40;fecha de inicio&#44; etiolog&#237;a sospechada&#44; ingresos previos&#44; estado basal seg&#250;n la clasificaci&#243;n de la New York Heart Association &#91;NYHA&#93;&#41;&#59; <span class="elsevierStyleItalic">c&#41;</span> comorbilidades&#59; <span class="elsevierStyleItalic">d&#41;</span> estado funcional y cognitivo basales &#40;medidos con el &#237;ndice de Barthel y el Short Portable Mental Status Questionnaire&#44; respectivamente&#41;&#44; y <span class="elsevierStyleItalic">e&#41;</span> datos cl&#237;nicos de ingreso &#40;presi&#243;n sangu&#237;nea&#44; frecuencia card&#237;aca&#44; peso&#44; altura&#44; s&#237;ntomas y signos de insuficiencia card&#237;aca y posible causa del evento de ICA&#41;&#46; Se dispone de electrocardiograma y radiograf&#237;a de t&#243;rax de todos los pacientes&#59; adem&#225;s&#44; es obligatorio disponer de un examen ecocardiogr&#225;fico reciente&#44; aunque en su ausencia se permite realizarlo bien durante el ingreso &#237;ndice o los 3<span class="elsevierStyleHsp" style=""></span>meses posteriores al alta&#46; Se estableci&#243; como valor de corte 50&#37; para distinguir entre ICFER &#40;&#60; 50&#37;&#41; e insuficiencia card&#237;aca con fracci&#243;n de eyecci&#243;n intermedia<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>preservada &#40;&#8805; 50&#37;&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Determinaci&#243;n de valores de prote&#237;na C reactiva y otros datos de laboratorio</span><p id="par0025" class="elsevierStylePara elsevierViewall">En el momento del ingreso se extrae una muestra de sangre de cada paciente&#46; En el laboratorio se determinan un hemograma completo y una bioqu&#237;mica b&#225;sica que incluye&#44; entre otras medidas&#44; pruebas de funci&#243;n renal y&#44; si est&#225;n disponibles&#44; an&#225;lisis de los valores plasm&#225;ticos de la troponina T ultrasensible&#44; del p&#233;ptido natriur&#233;tico &#40;BNP o Nt-pro-BNP&#41; y de PCR&#46; Para el caso concreto de la PCR&#44; se emple&#243; la t&#233;cnica de inmunoturbidimetr&#237;a&#44; consider&#225;ndose como concentraci&#243;n elevada los valores superiores a 10<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#46; Para la estimaci&#243;n de la tasa de filtrado glomerular &#40;TFGe&#41; se utiliz&#243; la f&#243;rmula del estudio Modification of Diet in Renal Disease-4 &#40;MDRD&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Objetivos</span><p id="par0030" class="elsevierStylePara elsevierViewall">El evento primario evaluado fue la mortalidad por cualquier causa a 3 meses&#46; Los eventos secundarios fueron&#58; mortalidad a los 3 meses desglosada por causas cardiovasculares y no cardiovasculares&#44; y el criterio combinado de mortalidad o reingreso por cualquier causa a 3 meses&#46; Con el fin de poder evaluar el valor de la PCR como factor pron&#243;stico de dichos eventos&#44; los pacientes fueron clasificados en terciles conforme con la concentraci&#243;n plasm&#225;tica de la misma &#40;asumiendo la correspondencia de los 3<span class="elsevierStyleHsp" style=""></span>terciles como marcadores de valores de PCR &#171;bajo&#187;&#44; &#171;medio&#187; y &#171;alto&#187;&#44; tal y como se ha efectuado en estudios previos<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">14&#44;16&#44;19&#44;24</span></a>&#41;&#46; Definimos como tiempo de supervivencia&#47;reingreso el n&#250;mero de d&#237;as transcurridos entre el d&#237;a del ingreso y el de fallecimiento&#47;ingreso no planificado&#44; respectivamente&#46; Tambi&#233;n evaluamos qu&#233; datos basales de los pacientes se asocian a la presencia de los valores m&#225;s elevados de PCR en el momento del ingreso hospitalario&#44; as&#237; como la correlaci&#243;n entre los niveles de PCR y la duraci&#243;n de la estancia hospitalaria &#40;DEH&#41; de dicho ingreso&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">An&#225;lisis estad&#237;stico</span><p id="par0035" class="elsevierStylePara elsevierViewall">Los resultados se muestran como media&#47;mediana &#40;desviaci&#243;n est&#225;ndar&#47;rango intercuart&#237;lico&#41;&#44; n&#250;mero &#40;&#37;&#41; y hazard ratio&#44; con un intervalo de confianza &#40;IC&#41; del 95&#37;&#46; La relaci&#243;n existente entre la medida de la PCR y los factores de confusi&#243;n potenciales se estudi&#243;&#44; para variables categ&#243;ricas&#44; usando la prueba de la chi al cuadrado o el test exacto de Fischer&#46; La prueba Kolmogorov-Smirnov se emple&#243; para comprobar la posible distribuci&#243;n normal de las variables cuantitativas&#46; La comparaci&#243;n de medias&#47;medianas se hizo con la prueba ANOVA&#44; para distribuciones normales&#44; y con el test de Wilcoxon Rank-Sum para variables continuas con distribuci&#243;n no normal&#46; Mediante un an&#225;lisis de regresi&#243;n log&#237;stica se determinaron los factores iniciales que&#58; <span class="elsevierStyleItalic">a&#41;</span> se correlacionan con los valores de PCR de ingreso&#44; y <span class="elsevierStyleItalic">b&#41;</span> se asocian de manera independiente a una mortalidad m&#225;s elevada por cualquier causa a 3 meses&#44; usando en este &#250;ltimo caso el valor de PCR como variable continua&#46; Mediante este procedimiento se estimaron las odds ratio sin ajustar y posteriormente ajustadas&#44; con un IC del 95&#37;&#46; En el an&#225;lisis de regresi&#243;n log&#237;stica se usaron las variables asociadas en el an&#225;lisis bivariante a&#241;adiendo edad y g&#233;nero&#46; El modelo ajustado final se obtuvo a trav&#233;s del m&#233;todo de regresi&#243;n con una p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;10 como criterio de inclusi&#243;n-eliminaci&#243;n&#46; Todos los an&#225;lisis se realizaron con el paquete estad&#237;stico Statistical Package for Social Sciences &#40;SPSS&#41; &#40;versi&#243;n 21&#46;0&#44; SPSS Inc&#46; Chicago&#44; IL&#44; Estados Unidos&#41;&#46; Los test fueron apareados y los valores de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 se consideraron estad&#237;sticamente significativos&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resultados</span><p id="par0040" class="elsevierStylePara elsevierViewall">En el momento de realizar este an&#225;lisis estaban incluidos en el registro RICA un total de 2&#46;616 pacientes&#44; disponi&#233;ndose de los valores de la PCR plasm&#225;tica en el ingreso en 1&#46;443 de ellos &#40;55&#37;&#41;&#46; Los perfiles demogr&#225;ficos y cl&#237;nicos entre los pacientes con y sin PCR disponible no difer&#237;an &#40;datos no publicados&#41;&#46; La mediana de la concentraci&#243;n de PCR fue 5&#44;4 &#40;1&#44;4-17&#44;3&#41; mg&#47;dl&#46; Para el an&#225;lisis de subgrupos se establecieron terciles de concentraci&#243;n de PCR definidos por los valores<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>2&#44;24<span class="elsevierStyleHsp" style=""></span>mg&#47;l &#40;bajo&#41;&#44; 2&#44;25-11&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;l &#40;intermedio&#41; y<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>11&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;l &#40;alto&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">La mediana de la edad de los 1&#46;443 pacientes fue de 80 a&#241;os &#40;73-85&#41; y de ellos el 47&#37; eran hombres&#46; En relaci&#243;n con las comorbilidades&#44; el 85&#37; ten&#237;a diagn&#243;stico de hipertensi&#243;n arterial&#44; el 47&#37; de diabetes mellitus y el 58&#37; de enfermedad renal cr&#243;nica&#46; Un tercio de los pacientes experimentaban el primer episodio de descompensaci&#243;n y aproximadamente el 40&#37; de ellos mostraban una ICFER &#40;estas y el resto de caracter&#237;sticas basales se resumen en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Los pacientes en el tercil de PCR elevada presentaron con m&#225;s frecuencia un codiagn&#243;stico de ingreso de infecci&#243;n respiratoria&#44; valores iniciales m&#225;s bajos del &#237;ndice Barthel y una peor funci&#243;n renal&#46; Los pacientes en el tercil de PCR m&#225;s baja mostraron valores m&#225;s altos de presi&#243;n sangu&#237;nea sist&#243;lica al ingreso&#46; El an&#225;lisis multivariado &#40;los datos no se muestran&#41; confirm&#243; la asociaci&#243;n independiente entre valores plasm&#225;ticos elevados de PCR al ingreso y la coexistencia de infecci&#243;n respiratoria coexistente&#44; presi&#243;n sangu&#237;nea sist&#243;lica m&#225;s baja y funci&#243;n renal alterada &#40;tanto por concentraciones de creatinina plasm&#225;tica como por TFGe&#41;&#44; sin que se encontrara asociaci&#243;n significativa con el resto de datos basales&#46;</p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Duraci&#243;n de la estancia hospitalaria</span><p id="par0055" class="elsevierStylePara elsevierViewall">La mediana de la DEH fue de 7&#44;0 &#40;5-11&#41; d&#237;as&#46; La <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> muestra la existencia de una asociaci&#243;n significativa entre valores elevados de la PCR al ingreso y DEH m&#225;s prolongada &#40;p&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Mortalidad y reingreso</span><p id="par0060" class="elsevierStylePara elsevierViewall">Durante los 3 meses de seguimiento&#44; 142 pacientes &#40;9&#44;8&#37;&#41; murieron y 140 &#40;9&#44;7&#37;&#41; ingresaron por un nuevo episodio de ICA u otras causas no programadas&#46; En total&#44; 268 pacientes &#40;18&#44;6&#37;&#41; o bien fallecieron o bien reingresaron durante la fase de seguimiento &#40;14 fueron dados de alta&#44; pero murieron posteriormente en casa&#41;&#46; Analizando los resultados por terciles de PCR al ingreso&#44; no se observan diferencias significativas entre los grupos &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41; ni en el evento principal de mortalidad a 3 meses&#44; ni en el resto de eventos secundarios relacionados con la mortalidad o el reingreso&#46; Finalmente&#44; el an&#225;lisis de regresi&#243;n log&#237;stica certific&#243; la falta de la asociaci&#243;n entre el valor de PCR al ingreso y la mortalidad a los 3 meses del alta &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discusi&#243;n</span><p id="par0065" class="elsevierStylePara elsevierViewall">Este estudio muestra que los pacientes ancianos que experimentan una hospitalizaci&#243;n por ICA y presentan en el momento del ingreso infecci&#243;n respiratoria&#44; presi&#243;n sangu&#237;nea sist&#243;lica baja y peor funci&#243;n renal presentan valores plasm&#225;ticos de la PCR significativamente m&#225;s altos&#59; asimismo&#44; que los pacientes con valores elevados de PCR en el momento del ingreso presentan estancias m&#225;s prolongadas&#46; Sin embargo&#44; no hemos confirmado que estos valores elevados de PCR en el ingreso posean valor predictivo de riesgo de mortalidad &#40;o reingreso&#41; a los 3 meses del alta&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">La relaci&#243;n existente entre valores elevados de la PCR y la infecci&#243;n respiratoria o la funci&#243;n renal deteriorada est&#225; en consonancia con la referida en publicaciones previas sobre ICA y otras enfermedades cardiovasculares agudas&#46; La infecci&#243;n&#44; adem&#225;s de ser una causa de descompensaci&#243;n de IC relevante&#44; habitual y bien reconocida<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">28</span></a>&#44; es uno de los principales factores patog&#233;nicos que desencadenan la s&#237;ntesis de PCR<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">29</span></a>&#46; Hay que destacar que la infecci&#243;n respiratoria aguda se consider&#243; presente tambi&#233;n en un n&#250;mero significativo de pacientes ubicados en el tercil inferior de PCR&#44; lo que posiblemente refleja o bien cierto grado de error diagn&#243;stico&#44; o bien que dichos pacientes estaban sufriendo una infecci&#243;n leve de v&#237;a respiratoria alta&#44; incapaz de originar un aumento significativo de los niveles de la PCR&#44; a diferencia de lo que ocurre en los casos de neumon&#237;a u otras infecciones bacterianas<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">El da&#241;o renal agudo en la ICA puede aparecer tanto de novo o como exacerbaci&#243;n de una enfermedad renal cr&#243;nica preexistente&#46; Es bien conocido el v&#237;nculo entre el da&#241;o renal y los valores elevados de la PCR&#44; cuya presencia refleja el estr&#233;s inflamatorio&#47;oxidativo relacionado con la patogenia del da&#241;o renal<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">30</span></a>&#46; En este sentido&#44; en nuestro estudio comprobamos que cuanto peor era la TFGe en el momento del ingreso&#44; m&#225;s altos eran los niveles de la PCR&#46; Como ocurr&#237;a con la infecci&#243;n respiratoria&#44; de nuevo un n&#250;mero considerable de pacientes &#40;52&#37;&#41; con una PCR normal presentaba funci&#243;n renal an&#243;mala en el momento del ingreso&#44; si bien la mayor&#237;a de dichos pacientes ya hab&#237;an sido diagnosticados de enfermedad renal cr&#243;nica con anterioridad y su TFGe permanec&#237;a estable&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Se ha indicado que la inflamaci&#243;n por s&#237; misma podr&#237;a ser un factor de riesgo independiente de desarrollo de hipertensi&#243;n arterial y sus complicaciones&#58; en hipertensos&#44; los niveles m&#225;s altos de PCR se relacionan con la rigidez vascular&#44; la arterioesclerosis&#44; el da&#241;o en &#243;rganos diana y el desarrollo de eventos cardiovasculares<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">31</span></a>&#46; Sin embargo&#44; aunque el diagn&#243;stico previo de &#171;hipertensi&#243;n&#187; e &#171;insuficiencia card&#237;aca hipertensiva&#187; se distribuy&#243; de forma uniforme entre los pacientes de los terciles de PCR &#40;y asimismo la &#171;crisis hipertensiva&#187; como factor de descompensaci&#243;n de la insuficiencia card&#237;aca&#41;&#44; los valores de presi&#243;n arterial sist&#243;lica fueron significativamente menores entre los pacientes con mayores valores de PCR&#46; Aunque este hallazgo pueda parecer contradictorio&#44; puede ser explicado si asumimos que un aumento de la respuesta inflamatoria podr&#237;a ser m&#225;s patente en la situaci&#243;n m&#225;s grave&#44; la ICA hipotensiva&#44; como se ha descrito en el shock cardiog&#233;nico que complica el s&#237;ndrome coronario agudo<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">31</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Aunque los ingresos hospitalarios por ICA est&#225;n aumentando&#44; la estancia media de los ingresos ha disminuido de forma progresiva&#46; Nuestro estudio refleja una DEH mediana consistente con los registros publicados para otros pacientes ancianos de ICA<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">32</span></a>&#46; La DEH en pacientes hospitalizados por ICA se ha relacionado con m&#250;ltiples factores&#44; como las caracter&#237;sticas basales del paciente&#44; las del episodio agudo de descompensaci&#243;n o la calidad de la atenci&#243;n hospitalaria<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">33</span></a>&#46; La DEH m&#225;s elevada observada entre los pacientes con valores de PCR m&#225;s altos podr&#237;a reflejar no solo la gravedad del episodio de ICA&#44; sino tambi&#233;n la presencia concomitante de infecci&#243;n respiratoria&#44; da&#241;o renal u otras complicaciones &#40;presentes en el momento del ingreso o sobrevenidas durante la estancia hospitalaria&#41;&#44; que podr&#237;an conducir a una compensaci&#243;n m&#225;s lenta del episodio de ICA&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">La utilidad de las concentraciones plasm&#225;ticas en el momento del ingreso de la PCR o de PCRus como herramienta para predecir el riesgo de reingreso o de muerte tras un evento de insuficiencia card&#237;aca ha sido evaluada en diferentes contextos y con distintas poblaciones de pacientes&#46; Los ensayos VERITAS<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">13</span></a> y ASCEND-HF<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">14</span></a> fueron llevados a cabo en cohortes de pacientes m&#225;s j&#243;venes&#44; relativamente homog&#233;neas y con predominio de ICFER&#46; Ambos estudios pusieron de manifiesto la no asociaci&#243;n entre la PCRus &#40;ASCEND&#41; o la PCR &#40;VERITAS&#41; con los acontecimientos adversos&#44; excepto una DEH m&#225;s larga en el caso del ASCEND&#44; y de un empeoramiento de la insuficiencia card&#237;aca a 30 d&#237;as y de mortalidad a 180 d&#237;as en el VERITAS &#40;an&#225;lisis univariante ajustado&#41;&#46; En relaci&#243;n con los estudios de cohortes&#44; los datos del estudio BASEL<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">18</span></a>&#44; llevado a cabo con pacientes parecidos a los nuestros &#40;aunque&#44; de nuevo&#44; la mayor&#237;a de ellos con ICFER&#41;&#44; mostraron que los valores plasm&#225;ticos de ingreso de la PCRus m&#225;s altos predec&#237;an&#44; despu&#233;s del ajuste multivariante&#44; un riesgo m&#225;s elevado de mortalidad a 2 a&#241;os&#44; as&#237; como del evento combinado de mortalidad y reingreso&#46; El Korean Heart Failure Registry<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">22</span></a>&#44; que incluye un numeroso grupo de pacientes heterog&#233;neos de ICA semejante a nuestra cohorte&#44; aunque de edad m&#225;s joven&#44; tambi&#233;n pone de manifiesto que los valores de ingreso de PCRus permiten predecir el riesgo de muerte a los 12 meses del ingreso &#237;ndice&#44; especialmente cuando se usan en combinaci&#243;n con los valores de los p&#233;ptidos natriur&#233;ticos&#46; Por &#250;ltimo&#44; se ha demostrado tambi&#233;n en la cohorte ATTEND<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">24</span></a> japonesa&#44; muy parecida a RICA&#44; el valor predictivo de los niveles aumentados de PCR para riesgo de muerte cardiovascular y no cardiovascular a los 6 meses del alta&#46; El resultado negativo de nuestro estudio entra en clara contradicci&#243;n con los de este &#250;ltimo&#59; una posible explicaci&#243;n para este hecho es que&#44; siendo casi comparables las tasas de reingreso y muerte a corto plazo de los pacientes de los terciles de valor PCR bajo y medio &#40;incluyendo a todos los pacientes con valor PCR &#171;normal&#187; definido por el punto de corte cl&#237;nico&#41;&#44; otras variables no evaluadas&#44; comunes en la poblaci&#243;n anciana &#40;adherencia farmacol&#243;gica&#44; comorbilidades&#44; deterioro funcional&#44; mayor riesgo de reingreso e ingreso en residencias de ancianos&#41; y no relacionadas con la insuficiencia card&#237;aca puedan desempe&#241;ar un papel relevante en la incidencia de efectos adversos que anule o compense la ejercida por el estado inflamatorio relacionado con el episodio de ICA&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">La principal fortaleza de nuestro estudio reside en el hecho de que deriva de un registro de insuficiencia card&#237;aca multic&#233;ntrico&#44; lo que permite incluir a un elevado n&#250;mero de pacientes de insuficiencia card&#237;aca representativos &#171;del mundo real&#187;&#46; Sin embargo&#44; debemos mencionar algunas limitaciones&#46; La primera es que no dispusimos de los valores de PCR de casi la mitad de los pacientes registrados&#44; lo que puede hacer que exista un cierto sesgo de selecci&#243;n &#40;sin embargo&#44; no hab&#237;a diferencias significativas de las caracter&#237;sticas basales entre las poblaciones con y sin valor de PCR disponible&#41;&#46; En segundo lugar&#44; la PCR se midi&#243; tan solo en el momento del ingreso&#44; por lo que no podemos proporcionar informaci&#243;n relativa al valor pron&#243;stico derivado del cambio de los valores plasm&#225;ticos de la PCR durante la estabilizaci&#243;n&#44; el alta o el seguimiento&#44; como s&#237; sucedi&#243; en el ensayo ASCEND<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">17</span></a> o&#44; en combinaci&#243;n con otros biomarcadores&#44; en el RELAX-AHF<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">34</span></a>&#46; La tercera limitaci&#243;n se relaciona con la falta de informaci&#243;n m&#225;s espec&#237;fica relacionada con factores que contribuyen al desarrollo de la ICA y que probablemente influyen sobre la PCR plasm&#225;tica&#44; como las causas&#44; la intensidad y el tratamiento de las infecciones respiratorias y no respiratorias&#46; En cuarto lugar&#44; los datos de seguimiento se restringieron al registro de la muerte o reingreso y sus causas&#59; no se consign&#243; ning&#250;n dato relacionado con los sucesos acaecidos tras el alta antes de estos eventos&#46; Y&#44; por &#250;ltimo&#44; aunque quiz&#225; sea la limitaci&#243;n m&#225;s importante&#44; faltan los datos de los pacientes que fallecieron durante el ingreso &#237;ndice&#59; posiblemente estos pacientes fueran los que experimentaron los episodios de ICA m&#225;s graves o complicados y&#44; seguramente&#44; con mayor aumento de la PCR asociado&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conclusi&#243;n</span><p id="par0100" class="elsevierStylePara elsevierViewall">Nuestros datos no apoyan el uso rutinario de las mediciones de PCR en ancianos con ICA para evaluar el riesgo a corto plazo de muerte o reingreso posterior al alta hospitalaria&#44; independientemente de su indicaci&#243;n para otros fines&#46; Son necesarios m&#225;s estudios que permitan valorar si efectuar de forma secuencial la medida de la PCR&#44; la combinaci&#243;n de PCR con otros biomarcadores&#44; el uso de la PCRus o un per&#237;odo de seguimiento m&#225;s largo pueden mejorar la capacidad pron&#243;stica de la PCR en poblaciones de pacientes ancianos con insuficiencia card&#237;aca pluripatol&#243;gicos y polimedicados&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicto de intereses</span><p id="par0105" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;Agradecimientos</p><p id="par0110" class="elsevierStylePara elsevierViewall">Queremos mostrar nuestro agradecimiento a todos los investigadores que participan en el Registro RICA&#46; Agradecemos tambi&#233;n al Centro de Coordinaci&#243;n del Registro RICA&#44; S&#38;H Medical Science Service&#44; por su tarea de control de calidad de los datos&#44; el apoyo log&#237;stico y el trabajo administrativo&#44; as&#237; como al profesor Salvador Ortiz &#40;Universidad Aut&#243;noma de Madrid&#41; y a los asesores estad&#237;sticos de S&#38;H Medical Science Service&#44; por su ayuda en el an&#225;lisis estad&#237;stico de los datos presentados en este art&#237;culo&#46;</p></span></span>"
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              "titulo" => "Duraci&#243;n de la estancia hospitalaria"
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    "fechaRecibido" => "2018-02-16"
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    "resumen" => array:2 [
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La prote&#237;na C reactiva &#40;PCR&#41; plasm&#225;tica ha sido evaluada como marcador pron&#243;stico en insuficiencia card&#237;aca aguda &#40;ICA&#41;&#46; Sin embargo&#44; no est&#225; confirmado que posea validez pron&#243;stica cuando la poblaci&#243;n de ICA analizada est&#225; constituida por pacientes de edad avanzada&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Analizamos los valores plasm&#225;ticos de PCR en todos los pacientes ingresados en servicios de medicina interna por ICA de cualquier tipo&#46; Evaluamos la asociaci&#243;n existente entre dichos valores&#44; las caracter&#237;sticas cl&#237;nicas basales de los pacientes y las tasas de mortalidad y reingreso por cualquier causa a los 3 meses del alta&#46; Para las comparaciones se estratific&#243; a los pacientes en terciles de valor de PCR bajo&#44; medio y alto &#40;&#60; 2&#44;24<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#44; 2&#44;25-11&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;l y<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>11&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#44; respectivamente&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 1&#46;443 pacientes&#44; con una mediana de edad de 80 a&#241;os &#40;rango intercuart&#237;lico 73-85&#41;&#59; de ellos&#44; 680 &#40;47&#37;&#41; eran hombres&#44; con una carga de comorbilidad moderada&#59; el 60&#44;1&#37; presentaba fracci&#243;n de eyecci&#243;n del ventr&#237;culo izquierdo preservada &#40;&#62; 50&#37;&#41;&#46; El an&#225;lisis multivariante confirm&#243; la existencia de una asociaci&#243;n independiente entre valores elevados de PCR al ingreso y la presencia de infecci&#243;n respiratoria&#44; presi&#243;n sist&#243;lica baja y funci&#243;n renal alterada&#46; Tres meses despu&#233;s del ingreso &#237;ndice&#44; un total de 142 pacientes &#40;9&#44;8&#37;&#41; hab&#237;an fallecido y 268 &#40;18&#44;6&#37;&#41; hab&#237;an reingresado o hab&#237;an muerto&#46; Los valores de la PCR en el momento del ingreso no se correlacionaron con la tasa de mortalidad por cualquier causa a los 3 meses &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;79&#41;&#44; ni con la tasa a los 3 meses de reingreso por cualquier causa &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;96&#41; o con la combinaci&#243;n de ambos acontecimientos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;96&#41;&#46; Sin embargo&#44; los valores altos de la PCR se asociaron a estancias hospitalarias m&#225;s prolongadas &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio no confirma la existencia de una asociaci&#243;n entre los valores de PCR plasm&#225;ticos presentes en el ingreso en los ancianos con ICA con un mayor riesgo de mortalidad o reingreso a los 3 meses&#46;</p></span>"
        "secciones" => array:4 [
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction and objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Plasma c-reactive protein &#40;crp&#41; has been tested as a prognostic marker in acute heart failure &#40;ahf&#41;&#46; Whether its measurement really provides significant prognostic information when applied to elderly patients with ahf episodes remains unclear&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We measured the plasma crp values of patients admitted because of any type of ahf to internal medicine services&#46; We evaluated the association of these values with the patients&#8217; baseline clinical characteristics and their 3-month posdischarge all-cause mortality or readmission rates&#46; For comparison purposes&#44; we divided the sample in tertiles of low&#44; medium and high crp values &#40;&#60;2&#44;24<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#44; 2&#44;25-11&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;l and<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>11&#44;8<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We included 1443 patients with a median age of 80 years &#40;interquartile range 73-85&#41;&#59; 680 &#40;47&#37;&#41; were men&#44; with a moderate comorbid burden&#46; 60&#46;1&#37; had preserved left ventricular ejection fraction &#40;&#62; 50&#37;&#41;&#46; Multivariate analysis confirmed an independent association between higher crp values and the presence of respiratory infection&#44; lower systolic blood pressure and deteriorated renal function upon admission&#46; Three months after the index admission&#44; a total of 142 patients &#40;9&#46;8&#37;&#41; had died&#44; and 268 &#40;18&#46;6&#37;&#41; had either been readmitted or died&#46; admission crp values did not correlate with 3-month all-cause mortality <span class="elsevierStyleItalic">&#40;P</span>&#61;0&#46;79&#41;&#44; 3-month all-cause readmission <span class="elsevierStyleItalic">&#40;P</span>&#61;0&#46;96&#41; or the combination of both events <span class="elsevierStyleItalic">&#40;P</span>&#61;0&#46;96&#41;&#46; However&#44; higher crp values were associated with a longer length of stay <span class="elsevierStyleItalic">&#40;P</span>&#60;0&#46;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Our study does not confirm an association between admission plasma crp values in elderly ahf patients and subsequent higher 3-month mortality or readmission risks&#46;</p></span>"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">ARA-II&#58; antagonistas del receptor de la angiotensina II&#59; BNP&#58; p&#233;ptido natriur&#233;tico cerebral&#59; EPOC&#58; enfermedad pulmonar obstructiva cr&#243;nica&#59; FEVI&#58; fracci&#243;n de eyecci&#243;n ventricular izquierda&#59; IECA&#58; inhibidores de la enzima conversora de angiotensina&#59; IMC&#58; &#237;ndice de masa corporal&#59; MDRD&#58; f&#243;rmula de Modification of Diet in Renal Disease&#59; NHYA&#58; New York Heart Association&#59; NT-pro-BNP&#58; prohormona N-terminal del p&#233;ptido natriur&#233;tico cerebral&#59; PAS&#58; presi&#243;n arterial sist&#243;lica&#59; PCR&#58; prote&#237;na C reactiva SCA&#58; s&#237;ndrome coronario agudo&#59; SPMSQ&#58; Short Portable Mental Status Questionnaire&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PCR 0&#44;1-2&#44;24 mg&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PCR 2&#44;25-11&#44;8 mg&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PCR 11&#44;9-302&#44;1 mg&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Pacientes&#44; n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;443&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">481&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">481&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">481&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Edad&#44; a&#241;os</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80 &#40;73-85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79 &#40;73-84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80 &#40;73-85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80 &#40;75-85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;093&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hombres&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">680 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">218 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">244 &#40;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">218 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;154&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">IMC&#44; kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;3 &#40;25&#44;0-32&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;4 &#40;25&#44;3-32&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;2 &#40;25&#44;0-32&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;3 &#40;25&#44;0-32&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;959&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Etiolog&#237;a de insuficiencia cardiaca</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Isqu&#233;mica&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">391 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">132 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">117 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">142 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;182&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hipertensiva&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">515 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">166 &#40;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">171 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">178 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;717&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Valvulopat&#237;a&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">276 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">101 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;416&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Otras&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">259 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">92 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">92 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">75 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;260&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Causa de insuficiencia card&#237;aca aguda</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>SCA&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28 &#40;5&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28 &#40;5&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35 &#40;7&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;563&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Crisis hipertensiva&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83 &#40;5&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29 &#40;6&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;4&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;514&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fibrilaci&#243;n auricular r&#225;pida&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">286 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">98 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">81 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">107 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;102&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Transgresi&#243;n diet&#233;tica&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41 &#40;2&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;3&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;3&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;1&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;081&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infecci&#243;n respiratoria&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">413 &#40;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">118 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">143 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">152 &#40;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;043&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Otras&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">529 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">192 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">180 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">157 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;059&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Insuficiencia card&#237;aca de novo</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleItalic">&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">443 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">151 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">140 &#40;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">152 &#40;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;648&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Insuficiencia card&#237;aca cr&#243;nica descompensada</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleItalic">&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">828 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">271 &#40;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">285 &#40;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">272 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;595&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Diabetes mellitus&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">673 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">232 &#40;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">223 &#40;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">218 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;657&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hipertensi&#243;n&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1220 &#40;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">402 &#40;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">403 &#40;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">415 &#40;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;435&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">PAS&#44; mmHg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136 &#40;120-156&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">140 &#40;121-160&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">135 &#40;120-152&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">135 &#40;120-157&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Frecuencia card&#237;aca&#44; lpm</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85 &#40;73-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82 &#40;70-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85 &#40;73-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85 &#40;75-101&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;073&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hemoglobina&#44; g&#47;dl</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;262&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Creatinina&#44; mg&#47;dl</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;2 &#40;0&#44;9-1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;1 &#40;0&#44;9-1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;2 &#40;0&#44;9-1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;2 &#40;1&#44;0-1&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">MDRD</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">60 ml&#47;min&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">841 &#40;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">251 &#40;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">273 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">317 &#40;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">BNP&#44; pg&#47;ml</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">674 &#40;345-1&#44;511&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">675 &#40;275-1&#44;507&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">772 &#40;318-1&#44;547&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">584 &#40;352-1&#44;292&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;645&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">NT-pro-BNP&#44; pg&#47;ml</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;127 &#40;1&#44;441-6&#44;912&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;899 &#40;1&#44;409-6&#44;173&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;200 &#40;1&#44;320-6&#44;046&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;343 &#40;1&#44;565-7&#44;685&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;224&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FEVI</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">50&#37;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">562 &#40;39&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">196 &#40;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">187 &#40;39&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">179 &#40;37&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;664&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">NHYA I-II</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleItalic">&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">878 &#40;62&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">292 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">285 &#40;61&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">301 &#40;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;668&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">NYHA III-IV</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleItalic">&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">530 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">173 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">184 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">173 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;668&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">&#205;ndice de Barthel</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">95 &#40;70-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">95 &#40;75-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">95 &#40;70-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;65-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">SPMSQ</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;187&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">EPOC&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">386 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">114 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">133 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;331&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Fibrilaci&#243;n auricular&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">793 &#40;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">251 &#40;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">263 &#40;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">279 &#40;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;191&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Medicaci&#243;n de alta</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IECA o ARA-II&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;126 &#40;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">385 &#40;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">375 &#40;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">366 &#40;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;334&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Betabloqueantes&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">962 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">327 &#40;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">325 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">310 &#40;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;446&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Antagonistas de la aldosterona&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">559 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">171 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">200 &#40;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">188 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;156&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Estatinas&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">700 &#40;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">238 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">218 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;214&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PCR 0&#44;1-2&#44;24 mg&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36 &#40;7&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;340&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mortalidad no cardiovascular&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;3&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;312&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45 &#40;9&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89 &#40;18&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Multivariante<br>OR &#40;IC del 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Edad&#44; a&#241;os</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hombres</span>&#44;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;97 &#40;0&#44;69-1&#44;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;887&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">IMC&#44; kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;96 &#40;0&#44;92-0&#44;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Etiolog&#237;a de insuficiencia card&#237;aca</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hipertensiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Valvulopat&#237;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Otras&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;44 &#40;0&#44;24-0&#44;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;32 &#40;0&#44;16-0&#44;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Causa de insuficiencia card&#237;aca aguda</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>SCA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;522&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Crisis hipertensiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fibrilaci&#243;n auricular r&#225;pida&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;519&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Transgresi&#243;n diet&#233;tica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;598&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infecci&#243;n respiratoria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Otras&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;408&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Insuficiencia card&#237;aca de novo</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;29 &#40;0&#44;17-0&#44;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Insuficiencia card&#237;aca cr&#243;nica descompensada</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;55 &#40;1&#44;71-3&#44;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;66 &#40;1&#44;17-2&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hipertensi&#243;n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;07 &#40;0&#44;65-1&#44;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;794&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">PAS&#44; mmHg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;99 &#40;0&#44;98-1&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Frecuencia card&#237;aca&#44; lpm</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;99 &#40;0&#44;99-1&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;190&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hemoglobina&#44; g&#47;dl</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;82 &#40;0&#44;75-0&#44;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;87 &#40;0&#44;78-0&#44;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Creatinina&#44; mg&#47;dl</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;63 &#40;1&#44;33-2&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;33 &#40;1&#44;06-1&#44;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">MDRD</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">60ml&#47;min</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;00 &#40;1&#44;36-2&#44;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">N&#46;S&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">BNP&#44; pg&#47;ml</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00 &#40;1&#44;00-1&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;614&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">NT-pro-BNP&#44; pg&#47;ml</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00 &#40;1&#44;00-1&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;024&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FEVI</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">50</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;87 &#40;0&#44;61-1&#44;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;449&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">NHYA I-II</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;35 &#40;0&#44;25-0&#44;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;42 &#40;0&#44;28-0&#44;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">NYHA III-IV</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;83 &#40;1&#44;97-4&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">&#205;ndice Barthel</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;97 &#40;0&#44;97-0&#44;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">SPMSQ</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;34 &#40;1&#44;25-1&#44;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;31 &#40;1&#44;22-1&#44;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">EPOC</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;27 &#40;0&#44;87-1&#44;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;211&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Fibrilaci&#243;n auricular</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;20 &#40;0&#44;84-1&#44;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Medicaciones de alta</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IECA o ARA-II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;36 &#40;0&#44;25-0&#44;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;36 &#40;0&#44;24-0&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Betabloqueantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;48 &#40;0&#44;34-0&#44;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;46 &#40;0&#44;30-0&#44;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Aldosterona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;69 &#40;0&#44;48-1&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Estatinas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;80 &#40;0&#44;56-1&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;201&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;00 &#40;0&#44;99-1&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;309&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas basales asociadas a mortalidad a 3 meses por cualquier causa &#40;an&#225;lisis de regresi&#243;n log&#237;stica&#41;</p>"
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