Revista Clínica Española (English Edition) Revista Clínica Española (English Edition)
Rev Clin Esp 2005;205:395-7 - Vol. 205 Num.8 DOI: 10.1157/13078253
Estrategias farmacológicas en la prevención del daño vascular
Pharmacological strategies in prevention of vascular injury
P. Fernández Jiméneza, J. Solera Santosa
a Servicio de Medicina Interna. Hospital General Universitario de Albacete.
Atherosclerosis is the most prevalent disease in the industrialized world and is an important cause of morbidity-mortality. This revision analyzes the most important studies regarding prevention and treatment of this entity, whose pathophysiological base is found in injury in the endothelial wall. The present trend is aimed at combined and intensive action on the cardiovascular risk factors, giving special attention to the diabetic patients. Increasingly lower thresholds are being established for the early onset of medical and pharmacological control. In this sense, early use of a single tablet with various componets (statins, aspirin, folic acid, diuretics, ACEI and beta blockers) capable of acting simultaneously on the principal factors is advised. However, more well designed prospective studies are needed to be able to conclude on action.
Rev Clin Esp 2005;205:395-7 - Vol. 205 Num.8 DOI: 10.1157/13078253