Original articleClinical Features of Cytomegalovirus Anterior Uveitis in Immunocompetent Patients
Section snippets
Methods
This was a retrospective review of patients with hypertensive anterior uveitis who were investigated and managed according to a standard protocol. All patients seen at the Uveitis Clinic of the Singapore National Eye Centre from January 2004 through December 2006 with hypertensive anterior uveitis had their aqueous analyzed for viral deoxyribonucleic acid (DNA) after giving informed consent. Where indicated, they also underwent full blood count analysis, erythrocyte sedimentation rate analysis,
Results
One hundred and four patients were seen during the study period who were eligible for inclusion. Two patients had bilateral involvement. All the patients consented to AC taps, and 105 eyes were tapped. The only eligible eye that did not have aqueous sampling was the second eye of a patient with bilateral simultaneous FHI, and only the more severely affected eye was tapped. In the other patient with bilateral involvement, the second eye was examined and determined to require treatment eight
Discussion
Viruses are increasingly being implicated as a cause of what previously had been considered to be idiopathic ocular inflammations, even in immunocompetent patients. CMV, HSV, VZV, and mumps viruses have been associated with corneal endotheliitis,3, 9, 13, 14, 15 HSV and CMV have been associated with PSS,4, 5, 16 and rubella and HSV have been associated with FHI.17, 18, 19
We found CMV DNA on Tetraplex PCR in 24 (22.8%) of our eyes with hypertensive anterior uveitis, 14 of which also had positive
Soon-Phaik Chee graduated from the National University of Singapore and became a Fellow of the Royal College of Ophthalmologists in 1990. She did her Ocular Inflammation Fellowship in Moorfields Eye Hospital, London, United Kingdom. Dr Chee is currently the Senior Consultant and Head of the Ocular Inflammation and Immunology Service at the Singapore National Eye Centre, and is an Associate Professor of the Department of Ophthalmology at Yong Loo Lin School of Medicine, National University of
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Soon-Phaik Chee graduated from the National University of Singapore and became a Fellow of the Royal College of Ophthalmologists in 1990. She did her Ocular Inflammation Fellowship in Moorfields Eye Hospital, London, United Kingdom. Dr Chee is currently the Senior Consultant and Head of the Ocular Inflammation and Immunology Service at the Singapore National Eye Centre, and is an Associate Professor of the Department of Ophthalmology at Yong Loo Lin School of Medicine, National University of Singapore.
See accompanying Editorial on page 769.