TY - JOUR T1 - FluoroType® MTB en líquido pleural para el diagnóstico de tuberculosis JO - Revista Clínica Española T2 - AU - Bielsa,S. AU - Bernet,A. AU - Civit,C. AU - Acosta,C. AU - Manonelles,A. AU - Porcel,J.M. SN - 00142565 M3 - 10.1016/j.rce.2020.04.010 DO - 10.1016/j.rce.2020.04.010 UR - https://www.revclinesp.es/es-fluorotype-mtb-liquido-pleural-el-articulo-S0014256520301193 AB - ObjetivosThis work aims to investigate the diagnostic accuracy of a nucleic acid amplification test (FluoroType MTB®) in pleural fluid (PF) and sputum to diagnose tuberculous pleural effusion (TPE). We also analyzed the increase in diagnostic accuracy of a second FluoroType MTB® test on a second thoracentesis sample when the first was negative. MétodosWe conducted a prospective single-center study that included 207 patients with pleural effusion (31 tuberculous and 176 due to other causes). Of the 31 cases of TPE, 21 (68%) were confirmed histologically or microbiologically; the other cases were considered probable. ResultadosThe operational characteristics of FluoroType MTB® in PF for identifying tuberculosis were a sensitivity of 13%, a specificity of 99%, a positive likelihood ratio of 11, and a negative likelihood ratio of 0.9. The diagnostic efficacy data for sputum samples were 21%, 91%, 2.4, and 0.9, respectively. PF and sputum cultures in solid and liquid media had greater sensitivity (36% and 31%, respectively). A second FluoroType MTB® test in PF was negative for 24 patients who had TPE and for whom the first FluoroType MTB® test was also negative. Only two (6.5%) patients with TPE had a confirmed diagnosis based exclusively on the positive results of the FluoroType MTB® in PF. ConclusiónDue to its low sensitivity, the FluoroType MTB® test in PF has a limited role in diagnosing tuberculous pleurisy. ER -