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DOI: 10.1016/j.rceng.2019.01.003
Available online 25 January 2019
Laboratory guidelines for the diagnosis of patients with cryoglobulinemic syndrome
Guía de laboratorio para el diagnóstico de pacientes con síndrome crioglobulinémico
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A. Mariscal-Rodrígueza,
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a.mariscal.rod@gmail.com

Corresponding author.
, L.M. Villar Guimeransb, M. López-Trascasac, M. Hernández Gonzálezd, E. Moga Naranjoa, on behalf of grupo de inmunoquímica de la Sociedad Española de Inmunología 1
a Servicio de Inmunología, Hospital de la Santa Creu i, Sant Pau, Barcelona, Spain
b Servicio de Inmunología, Hospital Ramón y Cajal, Madrid, Spain
c Unidad de Inmunología, Hospital Universitario La Paz, Madrid, Spain
d Servicio de Inmunología, Hospital Universitario Vall d’Hebron, Barcelona, Spain
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Received 15 October 2018. Accepted 25 October 2018
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Table 1. Classification and characteristics of the various cryoglobulins.
Table 2. Recommended laboratory protocol for processing cryoglobulin samples.
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Abstract

Cryoglobulinemic syndromes include a collection of manifestations that are found in various diseases and that share a pathophysiological mechanism: cryoglobulin deposit in vascular beds. For these syndromes, the presence of cryoglobulins is a diagnostic criterion, and their correct detection and characterization are therefore essential. The Immunochemistry Group of the Spanish Society of Immunology conducted a comprehensive clinical and methodological review, due to the interlaboratory heterogeneity in techniques, with the objective of providing a useful and effective tool for diagnosing cryoglobulinemic syndromes.

Keywords:
Cryoglobulinemic syndromes
Vasculitis
Cryoglobulins
Resumen

Los síndromes crioglobulinémicos comprenden un conjunto de manifestaciones que se encuentran en diversas enfermedades y que comparten un mismo mecanismo fisiopatológico: el depósito de crioglobulinas en lechos vasculares. La presencia de crioglobulinas es criterio diagnóstico de estos síndromes por lo que es imprescindible su correcta detección y caracterización. El Grupo de Inmunoquímica de la Sociedad Española de Inmunología ha realizado una revisión exhaustiva clínica y metodológica, debido a la heterogeneidad técnica interlaboratorios, con el objetivo de proporcionar una herramienta útil y efectiva para el diagnóstico de síndromes crioglobulinémicos.

Palabras clave:
Síndromes crioglobulinémicos
Vasculitis
Crioglobulinas

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