TY - JOUR T1 - Comprehensive clinical, molecular and histopathological analysis of bone marrow in chronic myeloproliferative neoplasia JO - Revista Clínica Española (English Edition) T2 - AU - Medina Vega,L. AU - Hernández Nieto,L. AU - Salido Ruíz,E. AU - Álvarez-Argüelles Cabrera,H. AU - Raya Sánchez,J.M. SN - 22548874 M3 - 10.1016/j.rceng.2018.11.013 DO - 10.1016/j.rceng.2018.11.013 UR - https://www.revclinesp.es/en-comprehensive-clinical-molecular-histopathological-analysis-articulo-S2254887419300918 AB - ObjectivesTo analyze the possible correlation between molecular changes in the JAK2, MPL and CALR genes, the morphological pattern of bone marrow and the clinical-hematologic profile of patients. Patients and methodsWe conducted a retrospective study that included 140 patients diagnosed with Philadelphia-negative myeloproliferative neoplasia (Ph-MPN) in a single center. ResultsIn essential thrombocythemia (ET), the patients with the JAK2 V617F mutation presented more leucocytes and neutrophils than patients who presented the CALR mutation, who had more platelets and a greater need for cytoreductive therapy. These findings support the fact that the mutational state in ET appears to define subtypes of patients with substantially different clinical courses and prognoses. In myelofibrosis, the mutational state appears to influence the histopathological changes found in the bone marrow biopsy, which did not occur in polycythemia vera or ET. ER -