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Vol. 217. Num. 8.November 2017
Pages 439-494
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Vol. 217. Num. 8.November 2017
Pages 439-494
Original article
DOI: 10.1016/j.rce.2017.09.001
Tp-e interval and Tp-e/QT ratio in patients with celiac disease
Intervalo Tp-e y ratio Tp-e/QT en pacientes con celiaquía
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K. Demirtaşa, Ç. Yaylaa,
Corresponding author
cagriyayla@gmail.com

Corresponding author.
, M. Yükselb, B. Açara, S. Ünala, A.G. Ertema, M. Kaplana, M.Y. Akpinarb, Z.M.Y. Kiliçb, E. Kayaçetinb
a Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey
b Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey
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Table 1. Basal characteristics and laboratory parameters of the study population.
Table 2. Electrocardiographic and echocardiographic characteristics of the study population.
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Abstract
Objectives

Celiac disease is a chronic immune-mediated disease of the small intestine. It has been known that dilated cardiomyopathy and ischemic coronary artery disease have become more frequent in patients with celiac disease. The aim of the study was to assess Tp-e interval and Tp-e/QT ratio in patients with celiac disease.

Material and methods

This study was conducted at a single center in collaboration with gastroenterology and cardiology clinics. Between January 2014 and June 2015, a total of 76 consecutive patients were enrolled (38 patients with celiac disease and 38 control subjects). Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram.

Results

Tp-e interval (64.2±11.0 vs. 44.5±6.0; p<0.001), Tp-e/QT ratio (0.18±0.02 vs. 0.13±0.02; p<0.001) and Tp-e/QTc ratio (0.16±0.02 vs. 0.11±0.01; p<0.001) were significantly higher in patients with celiac disease than control subjects. There was a significant positive correlation between Tp-e/QTc ratio and disease duration in patients with celiac disease (r=0.480, p=0.003) and also there was a significant positive correlation between Tp-e/QTc ratio and erythrocyte sedimentation rate (r=0.434, p<0.001).

Conclusions

Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with celiac disease. Whether these changes increase the risk of ventricular arrhythmia deserve further studies.

Keywords:
Celiac disease
Tp-e interval
Tp-e/QT ratio
Resumen
Objetivos

La enfermedad celíaca (EC) o celiaquía, es una enfermedad crónica del intestino delgado inmuno-mediada. Es bien sabido que la cardiomiopatía dilatada y la cardiopatía isquémica se han hecho frecuentes en los pacientes celíacos. El objetivo de este estudio fue evaluar el intervalo Tp-e y el ratio Tp-e/QT ratio en los pacientes con celiaquía.

Material y métodos

Este estudio se realizó en un único centro, en colaboración con los clínicos de gastroenterología y cardiología. Entre enero de 2014 y junio de 2015 se incluyeron a un total de 76 pacientes consecutivos (38 pacientes con celiaquía y 38 sujetos control). Se midieron el intervalo Tp-e y los ratios Tp-e/QT y Tp-e/QTc a partir del electrocardiograma de 12 derivaciones.

Resultados

El intervalo Tp-e (64,2±11 vs. 44,5±6; p<0,001), el ratio Tp-e/QT (0,18±0,02 vs. 0,13±0,02; p<0,001) y el ratio Tp-e/QTc (0,16±0,02 vs. 0,11±0,01; p<0,001) fueron significativamente superiores en los sujetos celíacos con respecto a los controles. Se observó una correlación significativa entre el ratio Tp-e/QTc y la duración de la enfermedad en los pacientes celíacos (r=0,48; p=0,003), y también una correlación positiva significativa entre el ratio Tp-e/QTc y la tasa de sedimentación eritrocitaria (r=0,434; p<0,001).

Conclusiones

Nuestro estudio reflejó que el intervalo Tp-e y los ratios Tp-e/QT y Tp-e/QTc se incrementaron en los pacientes celíacos. El hecho de que dichos cambios incrementen o no el riesgo de arritmia ventricular justifica la realización de estudios futuros.

Palabras clave:
Celiaquía
Intervalo Tp-e
Ratio Tp-e/QT

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